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mRNA delivery by Exosomal transfer into cells (EXOtic). EV containing the RNA packaging device CD63-L7Ae (which can bind to the C/Dbox in the 3′ UTR of any RNA structure), targeting module (RVG-Lamp2b to target CHRNA7), cytosolic delivery helper (Cx43 S368A), and mRNA (e.g., nluc-C/Dbox) efficiently produced from EV donor cells. Engineered EVs will be delivered to target cells, expressing CHRNA7, with the help of Cx43.
