TABLE 2.
Amino acid substitutions in genes potentially responsible for resistance in C. parapsilosis triazole-evolved strains (FLUEVO, VOREVO, POSEVO) compared to the parental CLIB 214 strain
| Gene | Strain(s) | C. albicans orthologue | Orthologue function | Amino acid substitution |
|---|---|---|---|---|
| CPAR2_807270 | FLUEVO, VOREVO | MRR1 | Activator of Mdr1 efflux pump |
A808T (for FLUEVO), N394Y (for VOREVO) |
| CPAR2_100280 | FLUEVO, VOREVO | C5_03940C_A | Putative multidrug resistance protein, upregulated by Efg1p |
F4L |
| CPAR2_105550 | POSEVO | ERG3 | C-5 sterol desaturase, role in ergosterol biosynthesis |
D14Y |