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Summary of the role of microRNAs (miRNAs) in tuberculosis (TB) pathogenesis.
| Function | Upregulated in TB | Dowregulated in TB |
|---|---|---|
| Inhibition of innate immunity | miR-26-5p, miR-132-3p, miR-155-5p | miR-29-3p |
| Suppression of inflammation | miR-21-5p, miR-27b-3p, miR-99b-5p, miR-125-5p, miR-146a-5p, miR-223-3p | let-7f, miR-20b-5p miR-142-3p |
| Inhibition of phagosome maturation and autophagy | miR-33 locus, miR-27a-5p, miR-144-5p, miR-889-5p | |
| Apoptosis inhibition | miR-155-5p, miR-325-3p |
