Author Correction: Non-Invasive Photoacoustic Imaging of In Vivo Mice with Erythrocyte Derived Optical Nanoparticles to Detect CAD/MI

Correction to: Scientific Reports 10.1038/s41598-020-62868-1, published online 06 April 2020

This Article contains errors in Figure 7: Panels (d), (e), (f), (g) and (h) are incorporated erroneously. Furthermore, the correct panels (b) and (d) are missing in the image. As a result, the Figure legend,

“Histochemical analysis. In Trichrome stained heart (a) 20 × , (b) 200 × exhibited ligated LAD coronary artery (black arrow) and its surrounding region with infarct stained with blue colored collagen fibers indicative of scarring/tissue necrosis. The viable muscle tissues are highlighted with red stain (white arrow). (c) Trichrome stained (100 ×) septum in between left and right ventricles is highlighted with blue collagen indicative of infract region. (d) Picrosirius red indicating degraded collagen (200 ×) and (e) polarized light was used to visualize collagen types (400 ×). (f) Oil Red-O was used to identify lipids in atherosclerotic lesions (200 ×). Mac-2 staining for (g) macrophages present with a dapi and (h) macrophage overlay (200 ×). (i) H&E stained (200 ×) liver histologically demonstrated normal portal tract, surrounding liver parenchyma without necrosis, inflammation, fibrosis or no other pathologic changes. Note: results presented here is based on 20 µM NETs. Note: results presented here is based on 20 µM NETs.”

should read:

“After the photoacoustic and fluorescence imaging the heart was harvested for histiochemical analysis. Trichrome stained heart (a) 20 × , (b) 100 × , (c) 200 × exhibited ligated LAD coronary artery (green arrow) and its surrounding region of infarct area (black arrow) stained with blue colored collagen fibers indicative of scarring/infarction. The viable muscle tissues are highlighted with red stain (white arrow). (d) Trichrome stain of the heart (20x), showing left ventricle (red arrow) with blue staining collagen fibers indicative of scarring/infarction and right ventricle (blue arrow) with bright red staining of intact viable myocytes (muscle tissue). Early thrombus (yellow arrow) is also observed. (e) Trichrome stained (100x) septum in between left and right ventricles is highlighted with blue collagen indicative of infract region. (f) H&E stained (200x) liver histologically demonstrating normal portal tract, surrounding liver parenchyma without necrosis, inflammation, fibrosis or no other cell necrosis.”

The correct version of Figure 7 and the correct Figure legend appear below as Figure 1.

Figure 1.

After the photoacoustic and fluorescence imaging the heart was harvested for histiochemical analysis. Trichrome stained heart (a) 20×, (b) 100×, (c) 200× exhibited ligated LAD coronary artery (green arrow) and its surrounding region of infarct area (black arrow) stained with blue colored collagen fibers indicative of scarring/infarction. The viable muscle tissues are highlighted with red stain (white arrow). (d) Trichrome stain of the heart (20×), showing left ventricle (red arrow) with blue staining collagen fibers indicative of scarring/infarction and right ventricle (blue arrow) with bright red staining of intact viable myocytes (muscle tissue). Early thrombus (yellow arrow) is also observed. (e) Trichrome stained (100×) septum in between left and right ventricles is highlighted with blue collagen indicative of infract region. (f) H&E stained (200×) liver histologically demonstrating normal portal tract, surrounding liver parenchyma without necrosis, inflammation, fibrosis or no other cell necrosis.