Figure 2.

Overview of human viruses where solid-state NMR contributed to the understanding of global organization, orientation in the membrane and protein structure and dynamics. Viral proteins investigated by solid-state NMR are labeled in red. (a) HIV-1 virion with envelope-embedded gp41 protein containing the fusion peptide and internal capsid. (b) Influenza virion with M2 ion channel. (c) Measles virion with nucleocapsid protein. (d) HBV virion with small surface protein S and internal capsid. (e) Membrane topology of HCV with p7 and NS4B membrane proteins. Panel (d) is reprinted from [86], Copyright (2014), with permission from Elsevier. Panel (e) is adapted from [87].