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HIV-1 NC is a zinc metalloprotein. (A) Amino acid sequence and zinc binding mode of the HIV-1NL4-3 NC protein. (B) NMR structure of HIV-1NL4-3 NC. The independently folded CCHC “zinc knuckle” domains behave like “beads on a string.” (C) Similarities of zinc-edge EXAFS spectra obtained for an isolated HIV-1 CCHC peptide (top) and for intact retroviruses [Mouse Mammary Tumor Virus (center) and Equine Infectious Anemia Virus (bottom)]. Panels (B,C) reproduced from [82], with permission.
