Figure 2.

Lipin 1 structure and posttranslational modifications. (A) The lipin 1 protein contains several serine and threonine phosphorylation sites (P). Additionally, lipin 1 is acetylated (AC), sumoylated (SU), and ubiquitinated (Ub). Lipin 1 contains highly conserved N-terminal lipin (N-LIP) and C-terminal lipin (C-LIP) domains. The nuclear localization signal (NLS) is within the poly basic domain (PBD). The haloacid dehalogenase domain (DxDxT) is the catalytic motif and the LxxIL motif are contained within the C-LIP domain. (B) Recent crystal structure data suggests the N-LIP and C-LIP domains, which are separated by a linker region, interact to form an immunoglobulin-like domain in the native state.