Figure 7.

Hippocampus gene expression is altered by in utero exposure to bisphoenol A (BPA), as verified by qPCR. A: Representative genes that are upregulated in the in utero BPA-treated male and female mice, including Ttr, Ptgs2, Calb2, and Ryr3 (Ttr: P = 0.05, male; Ptgs2: P = 0.02, male; Calb2: P = 0.0002, female; Ryr3: P = 0.02, female). B: Representative genes that are downregulated in the in utero BPA-treated male and female mice, including Pnkd, Hdac4, Nsmf, Dbi, Prkcg, Nnat, Tmem181, Git1, and Cck (Pnkd: P = 0.03, male; Hdac4: P = 0.02, male; Nsmf: P = 0.02, male; Dbi: P = 0.05, male; Prkcg: P = 0.05, male; Nnat: P = 0.02 and P = 0.002, males and females, respectively; Tmem181: P = 0.02 and P = 0.04, male and female, respectively; Git1: P = 0.04, male; Cck: P = 0.03, female). C: Representative genes that are differentially regulated in the in utero BPA-treated male versus female mice, including Pdk4, Dctn3, Atp1a3 (Pdk4: P = 0.05 and P = 0.007, males and females, respectively; Dctn3: P = 0.22 and P = 0.18, males and females, respectively; Atp1a3: P = 0.40 and P = 0.41, males and females, respectively). Bars: mean + standard error of the mean (SEM) of the results. * P < 0.05, ** P < 0.01, *** P < 0.001 (unpaired 2-tailed Student’s t-test), N = 15. Abbreviation: CT, control.