Table 2. Mendelian randomization estimates for effect of body mass index (BMI), type 2 diabetes (T2DM) and systolic blood pressure (SBP), alone and with adjustment for pre-eclampsia or eclampsia (PET), on the outcome of birthweight of the first child.
| Method | SNP number | OR | LCI 95% | UCI 95% | p-val | |
|---|---|---|---|---|---|---|
| BMI (1-SD mmHg ↑) | IVW | 545 | 0.99 | 0.97 | 1.02 | 0.52 |
| Weighted median | 0.99 | 0.96 | 1.03 | 0.66 | ||
| MR-Egger | 1.00 | 0.95 | 1.06 | 0.89 | ||
| MR-PRESSO | 0.99 | 0.97 | 1.01 | 0.43 | ||
| T2DM (logOR ↑) | IVW | 195 | 1.02 | 1.00 | 1.03 | 0.02 |
| Weighted median | 1.01 | 1.00 | 1.02 | 0.10 | ||
| MR-Egger | 1.03 | 1.00 | 1.06 | 0.06 | ||
| MR-PRESSO | 1.02 | 1.01 | 1.03 | 3.95 x10-3 | ||
| SBP (1-SD mmHg ↑) | IVW | 219 | 0.83 | 0.79 | 0.86 | 3.96 x10-18 |
| Weighted median | 0.83 | 0.80 | 0.87 | 1.84 x10-18 | ||
| MR-Egger | 0.84 | 0.73 | 0.96 | 0.01 | ||
| MR-PRESSO | 0.85 | 0.82 | 0.88 | 1.23 x10-16 | ||
| Multivariable MR adjusted for PET | 217 | 0.82 | 0.79 | 0.87 | 4.81 x10-14 |
IVW = inverse variance weighted with mixed random effects, MR-Egger = Mendelian randomization Egger, MR-PRESSO = Mendelian Randomization Pleiotropy RESidual Sum and Outlier, Multivariable MR = multivariable Mendelian randomization, SNP = single nucleotide polymorphism, SD = standard deviation, LCI= lower confidence interval, UCI = upper confidence interval, p-val = p-value.