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. Author manuscript; available in PMC: 2022 Jun 20.
Published in final edited form as: Science. 2022 Apr 14;376(6595):844–852. doi: 10.1126/science.abn3810

Figure 1. CCAN is assembled from a network of interdependent modules.

Figure 1

(A, B) Cryo-EM density map (A) and molecular architecture (B) of the apo-CCANΔCT fitted into the cryo-EM map with resolved OPQURFoot and HIKHead. (C) Atomic model of the apo-CCANΔCT with details of the CENP-N-CENP-M interface as well as CENP-O binding to the CENP-HI pocket shown as insets. (D) Cartoon schematic of the CCANΔCT modules.