Figure 2. Structure of the CCAN^ΔT-CENP-A^Nuc complex.

(A) Right panel shows the consensus CCAN^ΔT-5 CENP-A^Nuc cryo-EM map (transparent white) overlaid onto the composite CCAN^ΔT-CENP-A^Nuc cryo-EM density map based on individual cryo-EM maps for the CENP-A^Nuc-CENP-C^N and CCAN^ΔT-DNA reconstructions. Left panel: composite map alone. (B) Two orthogonal views of the CCAN^ΔT-CENP-A^Nuc complex depicted in cartoon representation for protein and space filling for DNA. CENP-A^Nuc has a diameter of 11 nm.