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. Author manuscript; available in PMC: 2022 Jul 5.
Published in final edited form as: Science. 2022 Jun 24;376(6600):eabh2841. doi: 10.1126/science.abh2841

Figure 5: TNF-induced glutaminolysis increases succinate levels in mycobacterium-infected macrophages in a RIP3- and PGAM5-dependent manner.

Figure 5:

(A and B) Quantification of succinate in zebrafish larvae 1 dpi with Mm or mock-injected, that are (A) wild-type (WT) or TNFhi treated with GPNA, BPTES, or vehicle and (B) TNFhi, TNFhi RIP3 morphants, or TNFhi PGAM5 morphants. Each point represents the mean of four independent experiments in A and two independent experiments in B. Horizontal bars represent pooled SD. ***P<0.001, ****P<0.0001 (one-way ANOVA with Tukey’s post-test).