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. Author manuscript; available in PMC: 2023 Mar 6.
Published in final edited form as: Leukemia. 2022 May 26;36(8):1969–1979. doi: 10.1038/s41375-022-01601-5

Figure 4. Sustained deprivation of CXCL12 produced by Prx1-MSCs does not affect LSC homing nor their localization in the bone marrow.

Figure 4

(A) Homing assay showing the frequency of CD45.1 leukemic cells in the BM of Prx1-Cxcl12-Mut and Prx1-Cxcl12-Ctrl mice 1, 3 and 24 hours post infusion of leukemic cells. (B) Leukemia infiltration in the peripheral blood (PB) of Prx1-Cxcl12-Mut and Prx1-Cxcl12-Ctrl 25 days after leukemia induction. (C) Spleen analysis showing: the frequency of CD45.1leukemic cells(left panel) and the requency of LSCs (CD45.1+,Linlow, c-Kithigh, Sca1-, CD34+, CD16/32+), 25 days post-transplant(right panel). Data are representative of at least 2 independent experiments. n=6 mice per genotype per experiment unless otherwise stated. Data are represented as mean and SD. * P< .05; ** P< .01; *** P< .001.