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. Author manuscript; available in PMC: 2023 May 25.
Published in final edited form as: Circulation. 2023 Apr 17;147(21):1606–1621. doi: 10.1161/CIRCULATIONAHA.122.061940

Figure 2). Defining the effect of upstream regulators and PAH-relevant stimuli on SOX17.

Figure 2)

Relative gene expression of SOX17 compared to ACTβ in control and patient ECFC following exposure to known PAH stimuli. Individual data points represent individuals, n=5 controls, n=11 patients. Vehicle/treatments in 2% FBS EC media. LPS, lipopolysaccharide (2µg/ml). DMOG, Dimethyloxalylglycine (100µM), BMP9, bone morphogenetic protein-9 (10ng/ml). Ordinary 1-way ANOVA within groups compared to baseline condition with Dunnett’s multiple comparisons test. **-p<0.01, ***-p<0.005, ****-p<0.001.