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. Author manuscript; available in PMC: 2023 Jul 20.
Published in final edited form as: Nature. 2023 May 1;617(7959):208. doi: 10.1038/s41586-023-06048-x

Retraction Note: The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Thomas R Cox, Robin M H Rumney, Erwin M Schoof, Lara Perryman, Anette M Høye, Ankita Agrawal, Demelza Bird, Norain Ab Latif, Hamish Forrest, Holly R Evans, Iain D Huggins, Georgina Lang, Rune Linding, Alison Gartland, Janine T Erler
PMCID: PMC7614786  EMSID: EMS179292  PMID: 37069265

The Editors have retracted this paper because, in their view, data in Extended Data Fig. 1d and Extended Data Fig. 4a are unreliable. Issues with the original antibody used in Extended Data Fig. 1d and 4a have been identified. The western blots showing an increase in secreted LOX in bone-trophic and hypoxic MDA-MB-231 cells, and shRNA knock-down of LOX in 4T1 cells, present unreliable bands. R.L. agrees with the retraction. All other authors disagree with the retraction and believe the findings are still valid.

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