Table 3. Univariate assessment of invasive and non-invasive variables.

	Hazard ratio (95% CI)	Univariate p-value
Age	1.01 (0.98-1.03)	0.6
Composite physiological index	1.06 (1.03-1.09)	<0.001
Male gender	1.51 (0.95-2.38)	0.08
Diagnosis of Idiopathic pulmonary fibrosis	1.94 (1.21-3.10)	0.006
Fibrosis score (Increase by 10%)	1.37 (1.15-1.63)	<0.001
Vasodilator treatment	0.62 (0.40-0.97)	0.04
Right heart catheter haemodynamics
Mean pulmonary artery pressure	1.00 (0.98-1.03)	0.7
Mean pulmonary artery pressure ≥25mmHg	1.15 (0.68-1.97)	0.6
Pulmonary vascular resistance	1.03 (0.96-1.10)	0.4
Cardiac Output	0.88 (0.73-1.01)	0.2
Echocardiography
Right ventricular systolic pressure	1.01 (0.99-1.01)	0.3
Right atrial area	1.00 (0.97-1.04)	0.8
Pulmonary acceleration time	1.00 (0.99-1.02)	0.7
RV:LVecho	1.07 (0.71-1.60)	0.7
Transannular plane systolic excursion	0.97 (0.93-1.02)	0.3
RV Fractional area change	1.01 (0.98-1.04)	0.5
CT Pulmonary Angiography
MPA diameter (per 1mm increase)	1.01 (0.96-1.06)	0.7
MPA diameter (>32mm)	1.50 (0.93-2.43)	0.1
MPADiameter:Aorta ratio	0.97 (0.84-1.13)	0.7
RV subjectively larger than LV	2.08 (1.16-3.74)	0.01
RV:LVaxial ratio	1.04 (0.99-1.07)	0.1
RV:LVaxial ratio ≥ 1.0	2.17 (1.19-3.97)	0.01
RV:LVlargest ratio	1.06 (1.01-1.11)	0.02
RV:LVlargest ratio ≥ 1.0	3.26 (1.49-7.15)	0.003
Ventricular septal bowing	1.30 (0.81-1.96)	0.3
RAtransverse	1.01 (0.99-1.03)	0.3
RAlongitudinal	1.02 (0.99-1.05)	0.09

Abbreviations: As per table 2.