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. 2020 Oct 23;11:1312. doi: 10.3389/fphar.2020.01312

Corrigendum: Ginsenoside Re Attenuates High Glucose-Induced RF/6A Injury via Regulating PI3K/AKT Inhibited HIF-1a/VEGF Signaling Pathway

Weijie Xie 1,, Ping Zhou 1,, Muwen Qu 2, Ziru Dai 1, Xuelian Zhang 1, Chenyang Zhang 1, Xi Dong 1, Guibo Sun 1,*, Xiaobo Sun 1,*
PMCID: PMC7645230  PMID: 33192497

In the original article, there was a mistake in Figures 3, 5 and 7 as published. The marked symbols “+” and “-”in Figures 3B, C, Figures 5C, D and Figure 7C were misplaced. The corrected Figures 3, 5 and 7 appear below.

Figure 3.

Figure 3

Ginsenoside Re attenuated HG-induced RF/6A cell injury and oxidative stress. (A) ROS levels were monitored using a fluorescence microscope. (B) Statistical analysis of ROS fluorescence intensity. The enzymatic activities of LDH (C), MDA (D), CAT (E), and GSH-Px (F) were detected by spectrophotometry. The data are presented as the mean ± standard error of the mean (n = 5). ##P < 0.01 versus the control group; *P < 0.05, **P < 0.01 versus the HG group. Scale bar, 50 μm.

Figure 5.

Figure 5

Effects of Ginsenoside Re on HG-triggered apoptosis in RF/6A cells. (A) Distribution map of apoptotic cells detected by annexin V/PI double staining. (B) Representative images captured with fluorescence microscopy showing TUNEL-stained RF/6A cells. (C) Quantitative analysis of the ratio of annexin V/PI-positive cells to total cells. (D) The ratio of TUNEL-positive cells. The results are expressed as the mean ± SE of the mean (n = 5). ##P < 0.01 versus the control group; **P < 0.01 versus the HG group. Scale bar, 50 μm.

Figure 7.

Figure 7

Re protects RF/6A cells via regulation of the PI3K/Akt pathway. (A) Akt and p-AKT expression detected by western blot. (B) The changes of related proteins after LY294002 (PI3K inhibitor) incubation. (C) Analysis of Akt and p-Akt expression. (DH) Statistic analysis of related protein levels. The results are presented as the mean ± SEM percentage of the control from three independent tests. ##P < 0.01 versus the control group; *P < 0.05, **P < 0.01 versus the HG group; $$P < 0.01 versus the HG+Re group.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.


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