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. 2020 Jan 22;24(Suppl 1):6–7. doi: 10.1007/s10157-020-01845-4

Correction to: Dotinurad: a novel selective urate reabsorption inhibitor as a future therapeutic option for hyperuricemia

Satoru Kuriyama 1,2,
PMCID: PMC7645461  PMID: 31970592

Correction to: Clinical and Experimental Nephrology 10.1007/s10157-019-01811-9

In the original publication of the article the presentation of Table 1 was incorrectly published. The corrected table (Table 1) is given below.

Table 1.

Clinical trials of dotinurad

References Clinical trails gov ID Study objectives Subjects or patients Dotinurad dose (day) Dosing period
[23] NCT02344862 Dose response, optimal dose and safety (phase 2a) Hyperuricemia 0.25 → 0.5 → 1,2,4 mg placebo 8 weeks
[24] NCT02416167 Dose response, optimal dose and safety (phase 2b) Hyperuricemia 0.25 → 0.5 → 0.5,1,2,4 mg placebo 12 weeks
[25] NCT03006445 Long-term efficacy and safety Hyperuricemia

0.5 → 1→2 mg

0.5 → 1→2 → 4 mg

34 or 58 weeks
[26] NCT02344875 PK, PD, and safety in elder subjects Elderly 1 mg Single dose
[27] NCT02347046 PK, PD, and safety in patients with CKD

CKD

Healthy

1 mg Single dose
[28] NCT03306667 PK, PD, and safety in patients with liver damage

Liver disease

Healthy

4 mg Single dose
[30] NCT03100318 Non-inferiority test to benzbromarone and evaluation of safety Hyperuricemia

0.5 → 1→2 mg benzbromarone

25 → 50 → 50 mg

14 weeks
[31] NCT03372200 Non-inferiority test to febuxostat and evaluation of safety Hyperuricemia

0.5 → 1→2 mg febuxostat

10 → 20 → 40 mg

14 weeks
[32] NCT03350386 PK and safety of oxaprozin in combination (Drug interaction) Healthy 4 mg → oxaprozin 600 mg → 4 mg + oxaprozin 600 mg Single dose 6 days
[33] NCT02837198 PD, PK, and safety in patient groups classified into G1 and G2 G1: overproduction type, G2: underexcretion type 1 mg → 1 mg + topiroxostat 80 mg 7 days
[34] NCT03375632 PD and safety in patient groups classified into G1 and G2 G1 and G2 0.5 → 1→2 → 4 mg 14 weeks

PK pharmacokinetics, PD pharmacodynamics, UA uric acid, CKD chronic kidney disease

The original article has been corrected.

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