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The cut-off determination and Kaplan–Meier curves analysis. (a) The optimal cut-off to categorise TSR as stroma-low and stroma-high was determined by maximally selected rank statistics method. (b) Kaplan–Meier survival curves of overall survival of stroma-low vs stroma-high categories in the discovery and validation cohorts. TSR, tumour-stroma ratio; HR, hazard ratio; CI, confidence interval .
