Figure 4.

Reversal of CDK6 Loss Mediated CpG Site Methylation Changes by CDK6 Re-expression

(A) Dendrogram of hierarchical clustering of BCR-ABL⁺ Cdk6^wt (WT, red), BCR-ABL⁺ Cdk6^−/− (KO, blue) and BCR-ABL⁺ Cdk6^−/−+Cdk6 (KO + CDK6, green) cells based on CpG site methylation.

(B) Heatmaps showing methylation values of differentially methylated CpG sites in 3 replicates (Rep 1–3) of BCR-ABL⁺ Cdk6^wt, BCR-ABL⁺ Cdk6^−/− and BCR-ABL⁺ Cdk6^−/−+Cdk6 cell lines. Values are depicted as percentage of methylation and range from 0% (dark blue) to 100% (dark red). See also Figures S6 and S7.