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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Hepatology. 2020 Nov 7;73(2):533–547. doi: 10.1002/hep.31313

Fig 5.

Fig 5.

HBV infection induces METTL3 expression levels. (A – C) The m6A methyltransferase (METTL3/14) or demethylase (FTO) mRNA levels in liver biopsies from patients as described in Fig 2A, Fig 4A, and PHH infected with HBV. The METTL3, METTL14, and FTO mRNA levels were determined by qRT-PCR. (D) PHH were infected with HBV. After 72 h, PHH were harvested to assess expression levels of indicated proteins. (E) The indicated proteins were analyzed in lysates from HBV expressing HepG2 cells (HepAD38 and HBV 1.3-mer transfected cells). (F) The indicated proteins were analyzed in lysates from HepG2 cells that individually transfected with FLAG-HBx, HBc, FLAG-Pol and HBs.