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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Anesthesiology. 2020 Dec 1;133(6):1223–1233. doi: 10.1097/ALN.0000000000003568

Fig. 2.

Fig. 2.

Visual predictive check (VPC) plots. Dexmedetomidine plasma concentration of (A) our oral study group (n=10) and (B) pooled intravenous study group (n=13). Solid black line indicates 50 percentiles and dashed black lines indicate 2.5 and 97.5 percentiles of observation. Shaded area indicates 95% prediction interval. The VPC plot confirms the adequacy of model predictions, showing no apparent deviations between model and data. The 95% confidence interval and median for observed data lies within the predicted intervals obtained by simulation.