Table 1.
Phenotype Summary
| Arthritis | IBD | HVD | iBALT | Bone Marrow Nodules | Oily Fur | Embryonic Death | Lifespan | |
|---|---|---|---|---|---|---|---|---|
| Tnfdel4/+ | – | – | – | + | + | No | No | >1 year (n = 24) |
| Tnfdel4/del4 | + | +++ | – | +++ | +++ | Yes | No | 300 days (n = 34) |
| Tnfdel5/+ | – | – | – | – | – | No | No | >1 year (NA) |
| Tnfdel5/del5 | – | – | – | – | – | No | No | >1 year (n = 31) |
| Tnfdel6/+ | – | – | – | – | – | No | No | >1 year (NA) |
| Tnfdel6/del6 | – | – | – | – | – | No | No | >1 year (n = 57) |
| Tnfdel4del5/+ | ++ | +++ | ++ | +++ | +++ | Yes | No | >200 days (n = 77) |
| Tnfdel4del5/del4del5 | NA | NA | NA | NA | NA | NA | Yes, E16.5 | NA |
| Tnfdel4del5/del4del5;Tnfr1+/− | +/+ | +++ | ++ | +++ | +++ | Yes | No | 100 days (n = 2) |
| Tnfdel4del6/+;Tnfr1+/+ | NA | NA | NA | NA | NA | NA | Yes, stage unknown | NA |
| Tnfdel4del6/+;Tnfr1+/− | ++++ | ++ | + | + | +++ | No | 80% death at birth (PN1) | 20 days (n = 19) |
| BPSM1m/+ | ++ | + | ++ | +++ | +++ | No | No | 200 days (n = 49) |
| BPSM1m/m | ++++ | + | ++++ | ++++ | +++ | No | No | 4–8 weeks (n = 68) |
| TNFΔARE/+ | ++ | ++ | ++ | ++ | + | No | No | 200 days |
| TNFΔARE/ΔARE | ++++ | ++++ | ++++ | ++++ | + | No | No | 4–12 weeks |
Summary of the phenotypes observed in mice with various mutations in Tnf 3′ UTR. For lifespan values, n refers to the number of mice that have reached the specified age.