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. 2008 Sep 30;39(5):247–253. [Article in Spanish] doi: 10.1157/13101799

Prevalencia de insuficiencia renal oculta estimada mediante fórmulas de cálculo del grado de función renal en hipertensos mayores de 60 años, remitidos para medición ambulatoria de la presión arterial☆

Prevalence of hidden renal failure calculated through formulas on the degree of renal function in hypertense patients over 60 referred to out-patients for blood pressure monitoring

Gerónimo Pozuelos Estrada 1, Luis Molina Martínez 1, Juan José Romero Perera 1, Natalio Díaz Herrera 1, Lourdes Cañón Barroso 1, Francisco Buitrago Ramírez 1,⁎
PMCID: PMC7659542  PMID: 17493450

Abstract

Objectives

To validate the Cockroft-Gault and the abbreviated Modification of Diet in Renal Disease (MDRD) formulas in a hypertense population aged over 60 and with blood pressure monitored in out-patients.To evaluate the prevalence of various stages of hidden chronic kidney disease in this population.

Design

Descriptive study of validation of diagnostic tests.

Setting

Urban primary care centre.

Participants

A total of 113 patients over 60 (53.8% female) with hypertension and no history of chronic kidney disease, on whom blood pressure could be monitored in a 24-hour session.

Main measurements

Calculation of the glomerular filtration rate. Validity parameters of diagnostic tests.

Results

Renal clearance estimated in the Cockroft-Gault and MDRD equations was similar (77.9 mL/min and 76.9 mL/min, respectively). There was 37.3% prevalence of chronic kidney disease, using the Cockroft-Gault equation; and 27.0%, using the MDRD. The degree of agreement between the two equations was excellent in classifying patients with stage-2 chronic kidney disease (kappa index = 0.9) and it was acceptable for stage-3 (kappa index = 0.5). In both equations, validity indexes were acceptable for the presence of microalbuminuria as a manifestation of renal damage.

Conclusions

There is a high prevalence of hidden chronic kidney disease in the hypertense population over 60 years old. Glomerular filtration should be determined systematically in these patients, even when their plasma creatinine figures are normal.

Key words: Chronic kidney disease, Glomerular filtration rate, Arterial hypertension, Elderly

Footnotes

☆

Estudio financiado por la redIAPP (Innovación e Integración de la Prevención y Promoción de la Salud en atención primaria), red temática de investigación cooperativa G03/170, aprobada por el Instituto de Salud Carlos III.

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