Table 2.
Checkerboard assays of each chitosan in combination with an antifungal drug against C. albicans SC5314. FIC, fractional inhibitory concentration.
| Antifungal Drug | Chitosan | FICindex |
|---|---|---|
| Fluconazole | 3 kDa chitosan | 0.5 ± 0.125 |
| ~15 kDa chitosan | 0.125 ± 0.035 | |
| 20–30 kDa chitosan | 0.113 ± 0.038 | |
| LMW chitosan | 0.118 ± 0.043 | |
| MMW chitosan | 0.041 ± 0.021 | |
| Amphotericin B | 3 kDa chitosan | 1.75 ± 0.25 |
| ~15 kDa chitosan | 1.625 ± 0.625 | |
| 20–30 kDa chitosan | 1.505 ± 0.495 | |
| LMW chitosan | 1.05 ± 0.02 | |
| MMW chitosan | 1.505 ± 0.495 | |
| Caspofungin | 3 kDa chitosan | 2.515 ± 1.485 |
| ~15 kDa chitosan | 1.078 ± 0.048 | |
| 20–30 kDa chitosan | 2.505 ± 1.495 | |
| LMW chitosan | 1.03125 ±0.12 | |
| MMW chitosan | 1.578 ± 0.453 |