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. 2020 Oct 22:ciaa1617. doi: 10.1093/cid/ciaa1617

Specific re-distribution of SARS-CoV-2 variants in the respiratory system and intestinal tract

Pengcheng Du 1,2,#, Chuan Song 1,2,#, Rui Li 1,2,#, Yangzi Song 1,2,#, Jiarui Li 1,2, Nan Ding 1,2, Ju Zhang 1,2, Rui Song 4, Junyan Han 1,2, Guiju Gao 4, Jinglin Yue 1,2, Ang Duan 1,2, Yanyi Huang 5, Jing An 6, Jianbin Wang 3,#, Fujie Zhang 4,#, Chen Chen 1,2,#, Hui Zeng 1,2,#,✉
PMCID: PMC7665415  PMID: 33086379

Abstract

Intra-host analysis of SARS-CoV-2 genomic sequences identified two viral haplotypes that comprised of three genetically linked mutations from the respiratory and intestinal tracts of a patient with COVID-19. Spatiotemporal data suggest that this patient initially had dual-infection of two SARS-CoV-2 variants, which subsequently re-distributed into the two systems.

Keywords: Severe acute respiratory syndrome coronavirus 2, dual-infection, organ specific re-distribution

Articles from Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America are provided here courtesy of Oxford University Press

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