Skip to main content
Oxford University Press - PMC COVID-19 Collection logoLink to Oxford University Press - PMC COVID-19 Collection
. 2020 Oct 16:jiaa656. doi: 10.1093/infdis/jiaa656

Independent side-by-side validation and comparison of four serological platforms for SARS-CoV-2 antibody testing

Bernd Jahrsdörfer 1,, Joris Kroschel 2, Carolin Ludwig 1, Victor Max Corman 3, Tatjana Schwarz 3, Sixten Körper 1, Markus Rojewski 1, Ramin Lotfi 1, Christof Weinstock 1, Christian Drosten 3, Erhard Seifried 4, Thomas Stamminger 5, Hans Jürgen Groß 2, Hubert Schrezenmeier 1
PMCID: PMC7665624  PMID: 33064789

Abstract

Highly sensitive and specific platforms for the detection of anti-SARS-CoV-2 antibodies are becoming increasingly important for (1) evaluating potential SARS-CoV-2 convalescent plasma donors, (2) studying the spread of SARS-CoV-2 infections and (3) identifying individuals with seroconversion. This study provides a comparative validation of four anti-SARS-CoV-2 platforms. Unique feature of this study is the use of a representative cohort of COVID-19-convalescent patients with mild-to-moderate disease course. All platforms showed significant correlations with a SARS-CoV-2 plaque-reduction-neutralization test, with highest sensitivities for the Euroimmun and the Roche platforms, suggesting their preferential use for screening of persons at increased risk of SARS-CoV-2 infections.


Articles from The Journal of Infectious Diseases are provided here courtesy of Oxford University Press

RESOURCES