FIGURE 2.

Convection-enhanced delivery (CED) of EPZ-6438 for the treatment of orthotopic human DIPG xenografts. A, Schematic overview of CED into the brainstem (upper left), tissue distribution of trypan blue by CED administration (upper right) and MRI following CED of gadolinium to the brainstem (lower left: axial view, lower right: sagittal view). Red arrows; gadolinium signals at infusion site. B, Experimental design for in Vivo efficacy study of EZH2 inhibitor (EPZ-6438) using CED or intraperitoneal (IP) administration in SF8628 DIPG xenografted models.