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. Author manuscript; available in PMC: 2020 Nov 16.
Published in final edited form as: Neuroscience. 2017 Jun 30;363:50–61. doi: 10.1016/j.neuroscience.2017.06.038

Figure 6. Cancer mice exhibited decreased opioid receptor expression in the spinal cord and brainstem.

Figure 6

(A) DOR mRNA expression in the spinal cord of mice with tongue cancer (n=6) was significantly decreased compared to sham mice (n=6). MOR or KOR mRNA expression in the spinal cord of mice with tongue cancer was not different from sham mice. (B) DOR and MOR protein expression in the spinal cord of mice with tongue cancer (n=5) were significantly decreased compared to sham mice (n=4). (C) MOR and DOR protein expression in the brainstem of mice with tongue cancer (n=5) were significantly decreased compared to sham mice (n=4). No difference was detected for DOR in the brainstem of mice with tongue cancer (n=5) compared to sham mice (n=4). Mann-Whitney U-test. *p<0.05; **p<0.01.