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. 2020 Oct 25;10(26):11921–11937. doi: 10.7150/thno.46006

Figure 7.

Figure 7

8-OHdG and EBV DNA could be prognostic markers for NPC patients. (A) Serum 8-OHdG concentrations in NPC patients were assessed using ELISA method. EBV DNA copies in serum of the corresponding NPC patients (n = 95) were detected by using an EBV fluorescence quantitative PCR diagnostic kit. The correlation between 8-OHdG and EBV DNA is shown by scatter plot; r (Pearson) = 0.452, p = 0.000. (B) Generation of a molecular subtyping model for NPC based on 8-OHdG and EBV DNA level. The percentage of 4 groups was calculated based on the level of 8-OHdG and EBV DNA. EBV DNA cut-off value was set as 4,000 copies/mL based on clinical guidance. The median score of 8-OHdG was set as cut-off value and divided patients into high and low groups. (C) Patients were classified into 3 risk groups based on 8-OHdG and EBV DNA level.