Table 1.
Correlation between clinicopathological characteristics of OSCC patients and ITGB2 expression in FLC and TILs
| FLCs | TILs | |||||||
|---|---|---|---|---|---|---|---|---|
| ITGB2 Low (%) | ITGB2 High (%) | p | ITGB2 Low (%) | ITGB2 High (%) | p | |||
| Gender | ||||||||
| Female | 45 (56.3%) | 18 (40.0%) | 27 (60.0%) | 0.308 | 45 (58.4%) | 27 (60%) | 18 (40%) | 0.099 |
| Male | 35 (43.8%) | 18 (51.4%) | 17 (48.6%) | 32 (41.6%) | 22 (62.9%) | 10 (28.6%) | ||
| Age | ||||||||
| < 60 | 38 (47.5%) | 17 (44.7%) | 21 (55.3%) | 0.964 | 36 (46.8%) | 28 (73.7%) | 8 (21.1%) | 0.04 |
| ≥ 60 | 42 (52.5%) | 19 (45.2.0%) | 23 (54.8%) | 41 (53.2%) | 21 (50.0%) | 20 (46.7%) | ||
| TNM | ||||||||
| I-II | 62 (77.5%) | 33 (53.2%) | 29 (46.8%) | 0.006* | 60 (77.9%) | 40 (64.5%) | 20 (32.3%) | 0.529 |
| III-IV | 18 (22.5%) | 3 (16.7%) | 15 (83.3%) | 17 (22.1%) | 9 (50.0%) | 8 (44.4%) | ||
| Differentiation | ||||||||
| Well | 52 (65.0%) | 25 (48.1%) | 27 (51.9%) | 0.451 | 49 (63.6%) | 34 (65.4%) | 15 (28.8%) | 0.162 |
| Moderate/poor | 28 (35.0%) | 11 (39.3%) | 17 (60.7%) | 28 (36.4%) | 15 (53.6%) | 13 (46.4%) | ||
| WPOI | ||||||||
| 1-3 | 44 (55.0%) | 24 (54.5%) | 20 (45.5%) | 0.058 | 42 (54.5%) | 29 (65.9%) | 13 (29.5%) | 0.511 |
| 4-5 | 36 (45.0%) | 12 (33.3%) | 24 (66.7%) | 35 (45.5%) | 20 (55.6%) | 15 (41.7%) | ||
| Nerve invasion | ||||||||
| No | 57 (71.3%) | 28 (49.1%) | 29 (50.9%) | 0.438 | 55 (84.6%) | 35 (61.4%) | 20 (35.1%) | 0.662 |
| Yes | 13 (16.3%) | 7 (63.6%) | 4 (36.4%) | 10 (15.4%) | 7 (63.6%) | 3 (27.3%) | ||
| DOI | ||||||||
| < 5 mm | 52 (65%) | 28 (53.8%) | 24 (46.2%) | 0.03* | 51 (66.2%) | 31 (59.6%) | 20 (38.5%) | 0.388 |
| ≥ 5 mm | 28 (35%) | 8 (28.6%) | 20 (71.4%) | 26 (33.8%) | 18 (64.3%) | 8 (23.6%) | ||
*, represented that differences were considered statistically significant with P<0.05. FLCs, fibroblast-like cells; TILs, tumor-infiltrating lymphocytes. WPOI, worst pattern of invasion. DOI, depth of invasion.