Skip to main content
NCBI home page
Atencion Primaria logoLink to Atencion Primaria
. 2008 Nov 18;37(9):517–521. [Article in Spanish] doi: 10.1157/13089079

Valor predictivo del síndrome metabólico en la gestación para el desarrollo de diabetes mellitus y factores de riesgo vascular en la madre y el hijo, a corto plazo tras el parto (gestaMET)☆

Predictive value of metabolic syndrome in pregnancy for the development of diabetes mellitus and factors of shortterm vascular risk for mother and child after birth (gestaMET)

Isabel Fernández Fernández a, Beatriz Pascual de la Pisa b,⁎; por Los investigadores del proyecto gestaMET1
PMCID: PMC7668951  PMID: 16756877

Abstract

Objectives

To evaluate the presence of diabetes mellitus (DM) or short-term alterations in glucose metabolism, obesity and vascular risk factors after birth in women with pregnancy metabolic syndrome (PMS).To evaluate the incidence of obesity, lipaemia, glucaemia disorder, blood pressure (BP), or lipid figures in the period after birth in children of women with PMS.

Design

Cohort study.

Setting

Forty two primary care centres.

Participants

Study cohort (SC): women with PMS and their children. Control cohort (CC): women without primary criteria of PMS and their children. Sample size: SC, 980 women and CC, also 980. Consecutive sampling.

Measurements

Mother: basic data, 75 g oral overload, lipid profile, insulinaemia, toxic habits, nutrition survey, and physical activity. Child: weight, height, BP, nutrition survey, glucaemia, insulinaemia, and lipid profile. Father: basic data, BP, glucaemia, lipid profile, insulinaemia, toxic habits, nutrition survey, and physical activity.We will study genes related to insulin resistance in all subjects.

Statistical analysis

Comparison of proportions with χ2 test; ANOVA to measure means. Evaluation of effect of intra-uteral exposure through logistical regression and COX regression, whilst controlling potentially confusing and interactive variables.

Discussion

This study will contribute to locating the moment when diabetes and vascular risk start and to finding the optimum moment for starting prevention strategies.

Key words: Pregnancy, Pregnancy diabetes, Diabetes mellitus

Footnotes

☆

Este proyecto ha sido parcialmente financiado por el Instituto de Salud Carlos III (RedIAPP G03/170) y por la Consejería de Salud de la Junta de Andalucía en la convocatoria del año 2004 (resolución del 27 de diciembre) publicado en el BOJA n.° 6 del 11 de enero de 2005.

Bibliografía

  • 1.Pallardo F., Herranz L., García-Ingelmo T. Early postpartum metabolic assessment in women with prior gestational diabetes. Diabetes Care. 1999;22:1053–1058. doi: 10.2337/diacare.22.7.1053. [DOI] [PubMed] [Google Scholar]
  • 2.Dalfra M.G., Lapolla A., Masin M. Antepartum and early postpartum predictors of type 2 diabetes development in women with gestational diabetes. Diabetes Med. 2001;27:675–680. [PubMed] [Google Scholar]
  • 3.Schaefer-Graf U.M., Buchanan T.A., Xiang A.H. Clinical predictors for a high risk for the development of diabetes mellitus in the early puerperium in women with recent gestational diabetes mellitus. Am J Obstet Gynecol. 2002;186:751–756. doi: 10.1067/mob.2002.121895. [DOI] [PubMed] [Google Scholar]
  • 4.Kim C., Newton K.M., Knopp R.H. Gestational diabetes and the incidence of type 2 diabetes. A systematic review. Diabetes Care. 2002;25:1862–1868. doi: 10.2337/diacare.25.10.1862. [DOI] [PubMed] [Google Scholar]
  • 5.Silverman B.L., Rizzo T.A., Cho N.H. The Northwestern University Diabetes in pregnancy Center. Long-term effects of the intrauterine environment. Diabetes Care. 1998;21(2):B142–B149. [PubMed] [Google Scholar]
  • 6.Vohr B.R., McGarvey S.T., Tucker R. Effects of maternal gestational diabetes on offspring adiposity at 4-7 years of age. Diabetes Care. 1999;22:1284–1291. doi: 10.2337/diacare.22.8.1284. [DOI] [PubMed] [Google Scholar]
  • 7.Stene L.C., Magnus P., Lie R.T. Joner G and the Norwegian Childhood Diabetes Study Group. Birth weight and childhood onset type 1 diabetes: population based cohort study. BMJ. 2001;322:889–892. doi: 10.1136/bmj.322.7291.889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Dabelea D., Knowler W.C., Pettitt D.J. Effect of diabetes in pregnancy of offspring: follow-up research in the Pima Indians. J Matern Fetal Med. 2000;9:83–88. doi: 10.1002/(SICI)1520-6661(200001/02)9:1<83::AID-MFM17>3.0.CO;2-O. [DOI] [PubMed] [Google Scholar]
  • 9.Merzouk H., Madani S., Boualga A. Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes. J Lipid Res. 2001;42:1152–1159. [PubMed] [Google Scholar]
  • 10.Simmons R.A., Templeton L.J., Gertz S.J. Intrauterine growth retardation leads to the development of type 2 diabetes in the rat. Diabetes. 2001;50:2279–2286. doi: 10.2337/diabetes.50.10.2279. [DOI] [PubMed] [Google Scholar]
  • 11.Lawlor D.A., Smith G.D., Ebrahim S. Birth weight of offspring and insulin resistance in late adulthood: cross sectional survey. BMJ. 2002;325:359–363. doi: 10.1136/bmj.325.7360.359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12.Fernández Fernández I., Ríos Bonnín C., Rufo Romero A. Síndrome metabólico en la gestación: prevalencia. Av Diabetología. 2000;16:15(A). [Google Scholar]
  • 13.Fernández Fernández I., Costa Mestanza C.J., Griera Borrás J.L. Estudio de la Tolerancia a la Glucosa en los 12 meses postparto de la Diabetes Gestacional. Med Clin (Barc) 1992;99:47–51. [PubMed] [Google Scholar]
  • 14.Cisneros Alcántara S., Machado Cano M.J., Rufo Romero A. Metabolismo alterado de la glucosa tras la diabetes gestacional. Aten Primaria. 1999;24(2):272 (A). [Google Scholar]

Articles from Atencion Primaria are provided here courtesy of Elsevier

RESOURCES