Correction to: Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection

Correction to: J Neuroinflammation 17, 273 (2020)

https://doi.org/10.1186/s12974-020-01949-4

Following publication of the original article [1], the authors noticed that there are several images for Fig. 2 that are missing from the published article. Presented here is the corrected Fig. 2. Also, the original article has been updated.

Fig. 2.

Increased uptake intensity of TSPO ligand DPA-713 in multiple brain regions in mice with global decreased expression of OPN. a Representative images after PET-CT reconstructed from a 45–60-min time period after injection of [11C] DPA-713 are shown. b–h Precision in sampling was increased by assessing eight independent measurements calculated over the 20–50-min uptake time period in the brain regions indicated are shown (mean pixel intensity in a region on interest (ROI). The time frame analyzed and the eight measurements calculated are shown in the brain region-specific time-activity curves (b–h, left panel, green highlighted region). The number of female mice in each group was: (n = 4, Buffer-OPN⁺, n = 4, Buffer-OPN⁻, n = 4, HIV-OPN⁺, n = 4, HIV-OPN⁺). The eight measurements from each mouse are shown as individual dots in the nested graphs (b–h, middle panel). Each group is indicated with a different color. The numbers on the HIV OPN+ and HIV OPN- section are the viral loads in copies/mL of each mouse. The data were analyzed using nested one-way ANOVA with Tukey’s multiple comparisons, with mean and standard deviation, and significance. The right panel in b–h shows linear regression between viral loads and TSPO uptake from the HIV-OPN+ group. i, j Other brain regions analyzed in the same manner as described and no significant differences between groups were detected