Table 3. Study End Points in the Primary Analysis in a Study of the Effect of an Emergency Department Care Bundle Among Older Patients With Acute Heart Failure.
| End point | Intervention (n = 199) |
Usual care (n = 303) | Difference (95% CI) | Adjusted ratio (95% CI) | Adjusted risk ratio (95% CI) | |
|---|---|---|---|---|---|---|
| Unadjusted | Adjusteda | |||||
| Primary, median (IQR) | ||||||
| Time alive and out of hospital at 30 d, d | 19.0 (0.0 to 24.0) | 19.0 (0.0 to 24.0) | 0.0 (–4.0 to 4.0) | –1.9 (–6.6 to 2.8) | 0.88 (0.64 to 1.21) | |
| Secondary, No. (%) | ||||||
| 30-day all-cause mortality | 16 (8.0) | 29 (9.7) (n = 299) | –1.7% (–7.1% to 3.8%) | 4.1% (–17.2% to 25.3%) | 1.17 (0.53 to 2.57) | |
| 30-day cardiovascular mortality | 10 (5.0) | 22 (7.4) (n = 299) | –2.3% (–7.0% to 2.3%) | 2.1% (–15.5% to 19.8%) | 1.12 (0.45 to 2.82) | |
| 30-day hospital readmission | 22 (14.3) (n = 154) | 37 (15.7) (n = 235) | –1.5% (–9.2% to 6.3%) | –1.3% (–26.3% to 23.7%) | 0.96 (0.48 to 1.95) | |
| Length of hospital stay, median (IQR), d | 8.0 (5.0 to 21.0) (n = 182) | 8.0 (5 to 16.0) (n = 269) | 0.0 (–1.8 to 1.8) | 2.5 (–0.9 to 5.8) | 1.22 (0.94 to 1.59) | |
| 2-fold rise in creatinine levelb | 2 (1.0) (n = 192) | 4 (1.4) (n = 287) | ||||
Abbreviation: IQR, interquartile range.
a
Differences, ratios, and risk ratios were adjusted for time period and cluster size (categorical) as fixed effects and cluster as a random effect. The difference is expressed as intervention minus control and the ratio as intervention/control.
b
Given the small numbers, no analysis was performed for the 2-fold rise in creatinine level end point.