Table 1.

Aggregate statistics for the 600-way alignment

Alignment	No. of genomes	Total bases	Instance-hours	Core-hours	Common ancestor size
Zoonomia	242	669 billion	68,166	1.9 million	1.73 Gb
B10K	363	400 billion	5,302	0.2 million	1.13 Gb
Combined	605	1.07 trillion	73,692	2.1 million	181 Mb

The increase in computational work for the mammal alignment compared with the bird alignment is largely caused by the increase in the pairwise alignment phase runtime because it scales quadratically with the size of the genomes being aligned.