Table 5.
Chr | Probe | Pos | Gene | TRE Start |
TRE End |
Effect size | eQTM P |
EWAS P |
TWAS P |
---|---|---|---|---|---|---|---|---|---|
Promoter | |||||||||
6 | cg11210880 | 11779911 | ADTRP | 11779280 | 11781280 | -0.43 | 1.1 × 10-12 | 7.6 × 10-9 | 4.0 × 10-11 |
1 | cg01062020 | 162382848 | SH2D1B | 162381928 | 162383928 | -0.2 | 1.7 × 10-6 | 2.0 × 10-6 | 9.8 × 10-11 |
20 | cg20895028 | 58533443 | CDH26 | 58531470 | 58533470 | -0.49 | 6.0 × 10-6 | 4.2 × 10-10 | 1.5 × 10-10 |
17 | cg18105842 | 7341440 | FGF11 | 7339591 | 7341591 | -0.23 | 3.6 × 10-9 | 8.5 × 10-7 | 1.5 × 10-10 |
20 | cg01352551 | 19191994 | SLC24A3 | 19191289 | 19193289 | -0.33 | 8.1 × 10-8 | 1.5 × 10-4 | 1.7 × 10-10 |
2 | cg14499385 | 190446494 | SLC40A1 | 190445537 | 190447537 | 0.48 | 1.3 × 10-10 | 6.6 × 10-4 | 3.9 × 10-10 |
13 | cg18341491 | 38174258 | POSTN | 38172981 | 38174981 | -0.7 | 2.9 × 10-8 | 6.3 × 10-7 | 8.2 × 10-10 |
17 | cg13606025 | 68070495 | KCNJ16 | 68069365 | 68071365 | -0.45 | 7.8 × 10-10 | 2.5 × 10-4 | 1.9 × 10-9 |
3 | cg13705284 | 58523313 | ACOX2 | 58522929 | 58524929 | -0.45 | 4.0 × 10-18 | 8.8 × 10-10 | 3.8 × 10-9 |
10 | cg19571004 | 135340850 | CYP2E1 | 135338866 | 135340866 | -0.49 | 5.2 × 10-21 | 3.3 × 10-6 | 3.9 × 10-9 |
17 | cg25170091 | 202716 | RPH3AL | 202633 | 204633 | -0.21 | 7.9 × 10-15 | 4.6 × 10-6 | 5.2 × 10-9 |
5 | cg00049323 | 472564 | LOC100288152 | 471350 | 473350 | 0.18 | 9.5 × 10-7 | 1.0 × 10-13 | 6.0 × 10-9 |
7 | cg23468130 | 114562060 | MDFIC | 114560208 | 114562208 | -0.28 | 1.1 × 10-7 | 2.2 × 10-4 | 9.1 × 10-9 |
8 | cg10054641 | 133773093 | TMEM71 | 133772914 | 133774914 | -0.2 | 1.0 × 10-12 | 1.6 × 10-11 | 1.9 × 10-8 |
3 | cg08450017 | 45984838 | CXCR6 | 45982972 | 45984972 | -0.46 | 2.0 × 10-32 | 1.8 × 10-6 | 2.5 × 10-8 |
Enhancer | |||||||||
3 | cg22012981 | 58522689 | ACOX2 | 58520920 | 58522840 | -0.86 | 3.1 × 10-31 | 2.0 × 10-11 | 3.8 × 10-9 |
16 | cg16219266 | 67433184 | FBXL8 | 67432850 | 67433250 | -0.4 | 3.3 × 10-6 | 1.1 × 10-5 | 1.2 × 10-8 |
17 | cg04204452 | 1479213 | MYO1C | 1479060 | 1479890 | 0.2 | 3.9 × 10-8 | 4.4 × 10-6 | 1.4 × 10-8 |
16 | cg16219266 | 67433184 | NOL3 | 67432850 | 67433250 | -0.34 | 1.0 × 10-5 | 1.1 × 10-5 | 2.3 × 10-8 |
3 | cg16209444 | 58522771 | KCTD6 | 58520920 | 58522840 | -0.29 | 1.0 × 10-9 | 1.1 × 10-8 | 3.0 × 10-8 |
11 | cg15453278 | 67134607 | RHOD | 67133100 | 67134930 | -0.14 | 1.7 × 10-5 | 5.1 × 10-5 | 1.9 × 10-7 |
7 | cg20813462 | 2646259 | TTYH3 | 2645630 | 2646750 | -0.18 | 1.5 × 10-6 | 2.4 × 10-3 | 3.9 × 10-7 |
17 | cg04204452 | 1479213 | ABR | 1479060 | 1479890 | 0.15 | 3.5 × 10-7 | 4.4 × 10-6 | 4.2 × 10-7 |
7 | cg20813462 | 2646259 | SNX8 | 2645630 | 2646750 | -0.15 | 1.5 × 10-6 | 2.4 × 10-3 | 6.3 × 10-7 |
16 | cg07261196 | 75601025 | KARS | 75600810 | 75601930 | 0.16 | 2.1 × 10-5 | 5.3 × 10-4 | 4.2 × 10-6 |
17 | cg01780984 | 79058859 | BAIAP2 | 79058690 | 79059450 | -0.26 | 1.4 × 10-8 | 7.8 × 10-4 | 1.4 × 10-5 |
12 | cg24437859 | 7066614 | PTMS | 7065730 | 7066810 | 0.16 | 9.0 × 10-6 | 6.9 × 10-5 | 2.1 × 10-5 |
17 | cg04204452 | 1479213 | SERPINF2 | 1479060 | 1479890 | 0.37 | 5.1 × 10-14 | 4.4 × 10-6 | 2.4 × 10-5 |
16 | cg16219266 | 67433184 | TRADD | 67432850 | 67433250 | 0.53 | 2.5 × 10-6 | 1.1 × 10-5 | 8.6 × 10-5 |
6 | cg19053046 | 33048254 | HLA-DPA1 | 33046460 | 33048440 | -0.34 | 6.8 × 10-15 | 3.2 × 10-4 | 8.6 × 10-5 |
The top 15 methylation-gene pairs are presented for each category (promoter or enhancer region). Results sorted by TWAS P value.29 A total of 143 mediation paths in the promoter region of the associated genes and 29 mediation paths in the enhancer region (lung) of the associated genes were identified. Only one mediation path was presented per gene. Mediation analysis was conducted using Baron and Kenny (1986).9