Table 6.

Top 30 Most Significant eQTM Methylation-Gene Pairs in EVA-PR Cohort That Replicated in a Publicly Available Dataset (GSE65205)

Associated Pairs		EVA-PR			GSE65205
Probe	Gene	Beta	P	FDR	Beta	P	FDR
cg05991820	ECHDC3	-1	5.1 × 10-98	7.2 × 10-92	-0.31	3.9 × 10-3	1.2 × 10-2
cg22933800	HLA-DQB1	0.75	1.7 × 10-76	1.2 × 10-70	1	7.9 × 10-20	5.7 × 10-16
cg07237979	LSP1	-0.67	4.6 × 10-69	3.0 × 10-63	-0.57	2.4 × 10-12	4.9 × 10-10
cg14332815	LDHC	-0.71	1.3 × 10-56	4.0 × 10-51	-1.1	1.5 × 10-18	5.3 × 10-15
cg10296238	SPATC1L	-0.31	1.1 × 10-51	2.5 × 10-46	-0.23	2.4 × 10-10	1.7 × 10-8
cg17117718	CRHR1-IT1	0.29	4.0 × 10-51	8.6 × 10-46	0.35	5.2 × 10-8	1.2 × 10-6
cg16145915	ZFAND2A	0.48	2.6 × 10-50	5.1 × 10-45	0.53	1.1 × 10-4	6.0 × 10-4
cg10626236	CDK11A	0.59	3.2 × 10-50	6.2 × 10-45	0.39	1.0 × 10-2	2.5 × 10-2
cg03190825	CYP4F11	-1.3	2.5 × 10-48	4.5 × 10-43	-0.41	6.7 × 10-3	1.8 × 10-2
cg22092521	CFD	-0.83	1.7 × 10-45	2.6 × 10-40	-1.2	1.2 × 10-6	1.4 × 10-5
cg11375102	TMEM204	-0.68	1.3 × 10-44	1.9 × 10-39	-1	1.7 × 10-14	1.2 × 10-11
cg24977027	THNSL2	-0.78	5.6 × 10-44	8.0 × 10-39	-1.2	4.6 × 10-13	1.3 × 10-10
cg05461841	ZG16B	-0.66	2.0 × 10-42	2.6 × 10-37	-0.71	1.4 × 10-4	7.2 × 10-4
cg06851207	PNMAL1	-0.79	2.1 × 10-42	2.7 × 10-37	-0.89	3.0 × 10-7	4.6 × 10-6
cg01878807	DHRS4-AS1	-0.42	4.3 × 10-42	5.4 × 10-37	-0.34	1.3 × 10-5	1.0 × 10-4
cg02926397	LY6D	-1.2	8.3 × 10-42	1.0 × 10-36	-2.5	6.6 × 10-10	3.8 × 10-8
cg02719634	SLC22A18AS	-0.28	5.8 × 10-41	6.6 × 10-36	-0.41	3.0 × 10-6	3.0 × 10-5
cg06846259	POMC	-0.5	5.9 × 10-41	6.6 × 10-36	-1	1.2 × 10-16	2.4 × 10-13
cg15176213	COX7A1	-0.85	6.3 × 10-41	6.9 × 10-36	-1.3	2.4 × 10-14	1.7 × 10-11
cg14815891	FRG1BP	-0.19	8.0 × 10-41	8.7 × 10-36	-0.26	1.3 × 10-4	7.0 × 10-4
cg24846343	GSTT2B	-0.79	4.2 × 10-39	4.2 × 10-34	-1	1.1 × 10-12	2.6 × 10-10
cg19059861	BPIFA1	-3.2	4.6 × 10-37	4.1 × 10-32	-3.9	1.4 × 10-8	4.1 × 10-7
cg22933800	HLA-DQA2	-0.49	9.0 × 10-37	7.8 × 10-32	-0.18	1.7 × 10-5	1.3 × 10-4
cg06322601	RASA4	0.18	3.8 × 10-35	3.0 × 10-30	0.08	1.6 × 10-2	3.7 × 10-2
cg05681977	SLC39A4	-0.37	6.4 × 10-34	4.7 × 10-29	-0.64	9.1 × 10-16	1.4 × 10-12
cg10207745	LINC01559	-0.86	7.3 × 10-34	5.2 × 10-29	-0.52	3.0 × 10-3	9.5 × 10-3
cg10807101	GSTM3	-0.43	3.4 × 10-33	2.3 × 10-28	-0.68	4.9 × 10-7	6.8 × 10-6
cg08450017	CXCR6	-0.46	2.0 × 10-32	1.3 × 10-27	-0.59	2.4 × 10-10	1.7 × 10-8
cg01850135	NLRC3	-0.34	8.3 × 10-32	5.2 × 10-27	-0.9	1.5 × 10-11	2.0 × 10-9
cg23161218	ACAP1	0.31	1.2 × 10-31	7.5 × 10-27	0.29	2.1 × 10-4	1.0 × 10-3

Replication defined as FDR P < .05 with effect in the same direction as in EVA-PR.