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. 2020 Jun 20;158(5):1841–1856. doi: 10.1016/j.chest.2020.05.601

Table 6.

Top 30 Most Significant eQTM Methylation-Gene Pairs in EVA-PR Cohort That Replicated in a Publicly Available Dataset (GSE65205)

Associated Pairs
EVA-PR
GSE65205
Probe Gene Beta P FDR Beta P FDR
cg05991820 ECHDC3 -1 5.1 × 10-98 7.2 × 10-92 -0.31 3.9 × 10-3 1.2 × 10-2
cg22933800 HLA-DQB1 0.75 1.7 × 10-76 1.2 × 10-70 1 7.9 × 10-20 5.7 × 10-16
cg07237979 LSP1 -0.67 4.6 × 10-69 3.0 × 10-63 -0.57 2.4 × 10-12 4.9 × 10-10
cg14332815 LDHC -0.71 1.3 × 10-56 4.0 × 10-51 -1.1 1.5 × 10-18 5.3 × 10-15
cg10296238 SPATC1L -0.31 1.1 × 10-51 2.5 × 10-46 -0.23 2.4 × 10-10 1.7 × 10-8
cg17117718 CRHR1-IT1 0.29 4.0 × 10-51 8.6 × 10-46 0.35 5.2 × 10-8 1.2 × 10-6
cg16145915 ZFAND2A 0.48 2.6 × 10-50 5.1 × 10-45 0.53 1.1 × 10-4 6.0 × 10-4
cg10626236 CDK11A 0.59 3.2 × 10-50 6.2 × 10-45 0.39 1.0 × 10-2 2.5 × 10-2
cg03190825 CYP4F11 -1.3 2.5 × 10-48 4.5 × 10-43 -0.41 6.7 × 10-3 1.8 × 10-2
cg22092521 CFD -0.83 1.7 × 10-45 2.6 × 10-40 -1.2 1.2 × 10-6 1.4 × 10-5
cg11375102 TMEM204 -0.68 1.3 × 10-44 1.9 × 10-39 -1 1.7 × 10-14 1.2 × 10-11
cg24977027 THNSL2 -0.78 5.6 × 10-44 8.0 × 10-39 -1.2 4.6 × 10-13 1.3 × 10-10
cg05461841 ZG16B -0.66 2.0 × 10-42 2.6 × 10-37 -0.71 1.4 × 10-4 7.2 × 10-4
cg06851207 PNMAL1 -0.79 2.1 × 10-42 2.7 × 10-37 -0.89 3.0 × 10-7 4.6 × 10-6
cg01878807 DHRS4-AS1 -0.42 4.3 × 10-42 5.4 × 10-37 -0.34 1.3 × 10-5 1.0 × 10-4
cg02926397 LY6D -1.2 8.3 × 10-42 1.0 × 10-36 -2.5 6.6 × 10-10 3.8 × 10-8
cg02719634 SLC22A18AS -0.28 5.8 × 10-41 6.6 × 10-36 -0.41 3.0 × 10-6 3.0 × 10-5
cg06846259 POMC -0.5 5.9 × 10-41 6.6 × 10-36 -1 1.2 × 10-16 2.4 × 10-13
cg15176213 COX7A1 -0.85 6.3 × 10-41 6.9 × 10-36 -1.3 2.4 × 10-14 1.7 × 10-11
cg14815891 FRG1BP -0.19 8.0 × 10-41 8.7 × 10-36 -0.26 1.3 × 10-4 7.0 × 10-4
cg24846343 GSTT2B -0.79 4.2 × 10-39 4.2 × 10-34 -1 1.1 × 10-12 2.6 × 10-10
cg19059861 BPIFA1 -3.2 4.6 × 10-37 4.1 × 10-32 -3.9 1.4 × 10-8 4.1 × 10-7
cg22933800 HLA-DQA2 -0.49 9.0 × 10-37 7.8 × 10-32 -0.18 1.7 × 10-5 1.3 × 10-4
cg06322601 RASA4 0.18 3.8 × 10-35 3.0 × 10-30 0.08 1.6 × 10-2 3.7 × 10-2
cg05681977 SLC39A4 -0.37 6.4 × 10-34 4.7 × 10-29 -0.64 9.1 × 10-16 1.4 × 10-12
cg10207745 LINC01559 -0.86 7.3 × 10-34 5.2 × 10-29 -0.52 3.0 × 10-3 9.5 × 10-3
cg10807101 GSTM3 -0.43 3.4 × 10-33 2.3 × 10-28 -0.68 4.9 × 10-7 6.8 × 10-6
cg08450017 CXCR6 -0.46 2.0 × 10-32 1.3 × 10-27 -0.59 2.4 × 10-10 1.7 × 10-8
cg01850135 NLRC3 -0.34 8.3 × 10-32 5.2 × 10-27 -0.9 1.5 × 10-11 2.0 × 10-9
cg23161218 ACAP1 0.31 1.2 × 10-31 7.5 × 10-27 0.29 2.1 × 10-4 1.0 × 10-3

Replication defined as FDR P < .05 with effect in the same direction as in EVA-PR.