Objectives
In this cohort of 35,318 people, we aimed at evaluating the presence of co‐morbidities in maternal deaths secondary to COVID‐19 infection in a middle‐income country.
Methods
Data were extracted from the epidemiological surveillance system of viral respiratory diseases of Mexico, which includes 475 monitoring units of viral respiratory diseases on pregnant women with confirmed (nasopharyngeal RT‐PCR) SARS‐CoV2 infection from April 1 to April 20, 2020.
Results
Among the 91 COVID‐19 confirmed pregnant women, there were 5 (5.5%) cases of maternal death. Of note, 4 out of 5 deaths occurred in women with comorbidities. Pregnant women who died were older (38 vs. 30 years) and more likely to have diabetes or obesity. Other risk factors such as advance maternal age >35 years old (OR: 17.5; 95% CI: 4.51‐67.8; p = 0.001), or non‐communicable diseases such as diabetes, hypertension, and obesity (OR: 22.46; 95% CI: 5.94‐85.01; p < 0.001), were more likely to be associated with mortality. Though obesity by itself was not significantly associated with mortality, there is a trend towards its inclusion as a risk factor.
Conclusions
Between 20 and 49 years the case fatality rate of COVID‐infection doubles for each decade. Advanced maternal age is linked to non‐communicable diseases during pregnancy and confers an increased risk of mortality. In conclusion, our findings may guide the health sector to oversee vulnerable pregnant women and assess the risk of deterioration.
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Supplementary Materials
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