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. 2013 Apr 5;28(2):126–128. [Article in Spanish] doi: 10.1016/S0212-6567(01)78912-3

Fracaso de la serología rápida para Helicobacter pylori como método diagnóstico en la consulta de atención primaria

Failure of rapid serology for Helicobacter pylori as diagnostic method in the primary care clinic

LM Valle a,*, J Valdepérez a, M Tirado a, D Verduras a, C Yus b, F Gomollón b
PMCID: PMC7677983  PMID: 11440650

Abstract

Objective

To evaluate the validity of a rapid serology test for diagnosing Helicobacter pylori infection in our area.

Design

Longitudinal, prospective study.

Setting

Urban primary care centre.

Measurements

As reference tests for defining the presence/absence of Helicobacter pylori, histology and the urease gastric mucous membrane test (Jatrox® test) were used. Both tests can be either positive or negative, without intermediate values.

Results

47 consecutive patients were included. Histology (confirmed with the urease test) showed infection in 38 cases (80.85% prevalence). The results of rapid serology (95% CI) were: sensitivity 0.66 (0.51-0.81), specificity 1 (1-1), positive predictive value 1 (1-1), and negative predictive value 0.41 (0.2-0-61).

Conclusions

In a population with high prevalence of infection, a positive in the rapid serology test confirms infection. However, a negative does not discount infection, which significantly reduces the test’s overall diagnostic value. This confirms in the primary care context the findings of hospital-based studies.

Key words: Rapid serology, Helicobacter pylori, Diagnostic method

Bibliografía

  • 1.Sáinz R., Borda F., Domínguez E., Gis-bert J.P., Grupo Conferencia Española de Consenso Conferencia Española de Consenso sobre la infección por Helicobacter pylori. Rev Esp Enferm Digest. 1999;91:777–784. [PubMed] [Google Scholar]
  • 2.Marshall B.J. Helicobacter pylori. Am J Gastroenterol. 1994;89(Supl):116–128. [PubMed] [Google Scholar]
  • 3.Pérez-Trallero E., Montes M., Alcorta M., Zubillaga P., Tellería E. Non-endoscopic method to obtain Helicobacter pylori for culture. Lancet. 1995;345:622–623. doi: 10.1016/s0140-6736(95)90524-3. [DOI] [PubMed] [Google Scholar]
  • 4.Hackelsberger A., Schultze V., Peitz U., Günter T., Nilius M., Diete U. Performance of a rapid whole blood test for Helicobacter pylori in primary care: a German multicentre study. Helycobacter. 1998;3:179–183. doi: 10.1046/j.1523-5378.1998.08002.x. [DOI] [PubMed] [Google Scholar]
  • 5.Gisbert J.P. Revisión crítica de los métodos diagnósticos de infección por Helicobacter pylori. Gastroenterol Hepatol. 2001 en prensa. [PubMed] [Google Scholar]
  • 6.Gisbert J.P., Cruzado A.I., Cabrera M.M., Carpio D., Benito L.M., Pérez Poveda J.J. Serología «rápida» para el diagnóstico de infección por H. pylori. Estudio de su validez frente a un patrón de referencia y de su concordancia con la serología «clásica». Gastroenterol Hepatol. 2000;23:159–164. [PubMed] [Google Scholar]
  • 7.Kroser J.A., Faigel D.O., Furth E.E., Metz D. Comparison of rapid office-based serology with formal laboratory-based ELISA testing for diagnosis of Helicobacter pylori gastritis. Dig Dis Sci. 1998;43:103–108. doi: 10.1023/a:1018832306135. [DOI] [PubMed] [Google Scholar]
  • 8.Sáinz R., Borda F., Domínguez E., Gisbert J.P. Conferencia Española de Consenso sobre la infección por Helicobacter pylori. Rev Esp Enferm Dig. 1999;91:777–784. [PubMed] [Google Scholar]
  • 9.Patel P., Khulusi S., Mendall M.A., Lloyd R., Jazrawi R., Maxwell J.D. Prospective screenig of dyispeptic patients by Helicobacter pylori serology. Lancet. 1995;346:1315–1318. doi: 10.1016/s0140-6736(95)92340-3. [DOI] [PubMed] [Google Scholar]
  • 10.Cohen H., Laine L. Endoscopic methods for the diagnosis of Helicobacter pylori. Aliment Pharmacol Ther. 1997;11(Supl 1):3–9. doi: 10.1046/j.1365-2036.11.s1.2.x. [DOI] [PubMed] [Google Scholar]
  • 11.Huelin J., Sánchez-Galdón S., Cárdenas A., Ibáñez J., España P., De la Cruz J. Estudio comparativo entre Helisal TM Rapid Blood y ELISA, Jatrox y anatomía patológica en el diagnóstico de la infección por Helicobacter pylori. Rev Esp Enferm Dig. 1996;88:825–827. [PubMed] [Google Scholar]
  • 12.Graham D.Y., Evans D.J., Peacock J., Baker J.T., Schrier W.H. Comparison of rapid serological tests (FlexSureHP and Quick Vue) whith conventional ELISA for detection of H. pylori infection. Am J Gastroenterol. 1996;91:942–947. [PubMed] [Google Scholar]
  • 13.Oksanen A., Veijola L., Sipponen P., Schauman K.O., Rautelin H. Evaluation of Pyloroiset screen, a rapid whole-blood diagnostic test for Helicobacter pylori infection. J Clin Microbiol. 1998;92:2119–2123. doi: 10.1128/jcm.36.4.955-957.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Moayyedi P., Carter A.M., Catto A., Heppell R.M., Grand P.J., Axon A.T.R. Validation of a rapid whole blood test for diagnosing Helicobacter pylori infection. BMJ. 1997;314:119. doi: 10.1136/bmj.314.7074.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15.Stone M.A., Mayberry J.F., Wicks A.C.B., Livsey S.A., Stevens M., Swann R.A. Near patient testing for Helicobacter pylori: a detailed evaluation of the Cortecs Helisal Rapid Blood test. Eur J Gastroenterol Hepatol. 1997;9:257–260. doi: 10.1097/00042737-199703000-00007. [DOI] [PubMed] [Google Scholar]

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