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. 2008 Nov 18;37(4):221–230. [Article in Spanish] doi: 10.1157/13085953

¿Podemos mejorar el tratamiento y el control de las enfermedades crónicas?

Can we improve management and control of chronic diseases?

D Yánez-Cadena 1, A Sarría-Santamera 1,, F García-Lizana 1
PMCID: PMC7679849  PMID: 16545267

Abstract

Objetivo

Investigar la efectividad de diferentes estrategias destinadas a mejorar la calidad y los resultados de las intervenciones en el tratamiento de las enfermedades crónicas.

Metodología

Revisión sistemática de la bibliografía.

Criterios de inclusión

Ensayos clínicos en lengua inglesa o española que evalúen la efectividad de distintas intervenciones para mejorar los resultados asistenciales del asma, la diabetes, la hipertensión y la insuficiencia cardíaca. Las intervenciones se clasifican de acuerdo con un modelo conceptual en 6 categorías: cambios organizativos, participación comunitaria, sistemas de información, diseño de la práctica clínica, apoyo a la toma de decisiones y de autocontrol. Los resultados evaluados fueron: utilización de servicios de salud, tratamiento clínico, resultados clínicos, calidad de vida, satisfacción e indicadores de capacidad de autocontrol.

Resultados

Se incluyeron 37 estudios que incorporaban 38 intervenciones. Las intervenciones más frecuentes son las que investigan los cambios en el de diseño asistencial, seguidas de las que analizan el efecto de los sistemas de información y apoyo a la toma de decisiones. Las intervenciones más complejas en número de intervenciones, incluido el apoyo para el autocontrol, mostraron una mayor probabilidad de tener efectos positivos en el tratamiento y en los resultados clínicos. Pocas intervenciones consiguen mejoras en utilización de servicios, aunque sí se observaron sustanciales mejoras en los resultados percibidos.

Conclusiones

Para mejorar la calidad asistencial y la efectividad en el control de las enfermedades crónicas es preciso adoptar una visión sistemática que incluya un sistema sanitario proactivo y pacientes protagonistas activos del tratamiento de su enfermedad. Los programas así diseñados deben combinar, al menos, estrategias organizativas, de diseño asistencial y de autocontrol.

Palabras clave: Atención primaria, Calidad asistencial, Efectividad, Enfermedades crónicas

Bibliografía

  • 1.The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus The Diabetes Control and Complications Trial Research Group. N Engl J Med. 1993;329:977–986. doi: 10.1056/NEJM199309303291401. [DOI] [PubMed] [Google Scholar]
  • 2.Berlowitz D.R., Ash A.S., Hickey E.C., Friedman R.H., Glickman M., Kader B. Inadequate management of blood pressure in a hypertensive population. N Engl J Med. 1998;339:1957–1963. doi: 10.1056/NEJM199812313392701. [DOI] [PubMed] [Google Scholar]
  • 3.McClain M.R., Wennberg D.E., Sherwin R.W., Steinmann W.C., Rice J.C. Trends in the diabetes quality improvement project measures in Maine from 1994 to 1999. Diabetes Care. 2003;26:597–601. doi: 10.2337/diacare.26.3.597. [DOI] [PubMed] [Google Scholar]
  • 4.Von Korff M., Gruman J., Schaefer J., Curry S.J., Wagner E.H. Collaborative management of chronic illness. Ann Intern Med. 1997;127:1097–1102. doi: 10.7326/0003-4819-127-12-199712150-00008. [DOI] [PubMed] [Google Scholar]
  • 5.Campbell M., Fitzpatrick R., Haines A., Kinmonth A.L., Sandercock P., Spiegelhalter D. Framework for design and evaluation of complex interventions to improve health. BMJ. 2000;321:694–696. doi: 10.1136/bmj.321.7262.694. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Renders C.M., Valk G.D., Griffin S.J., Wagner E.H., Eijk V.J., Assendelft W.J. Interventions to improve the management of diabetes in primary care, outpatient, and community settings: a systematic review. Diabetes Care. 2001;24:1821–1833. doi: 10.2337/diacare.24.10.1821. [DOI] [PubMed] [Google Scholar]
  • 7.Norris S.L., Engelgau M.M., Narayan K.M. Effectiveness of self-management training in type 2 diabetes: a systematic review of randomized controlled trials. Diabetes Care. 2001;24:561–587. doi: 10.2337/diacare.24.3.561. [DOI] [PubMed] [Google Scholar]
  • 8.Boulware L.E., Daumit G.L., Frick K.D., Minkovitz C.S., Lawrence R.S., Powe N.R. An evidence-based review of patient-centered behavioral interventions for hypertension. Am J Prev Med. 2001;21:221–232. doi: 10.1016/s0749-3797(01)00356-7. [DOI] [PubMed] [Google Scholar]
  • 9.Norris S.L., Lau J., Smith S.J., Schmid C.H., Engelgau M.M. Self-management education for adults with type 2 diabetes: a meta-analysis of the effect on glycemic control. Diabetes Care. 2002;25:1159–1171. doi: 10.2337/diacare.25.7.1159. [DOI] [PubMed] [Google Scholar]
  • 10.Norris S.L., Nichols P.J., Caspersen C.J., Glasgow R.E., Engelgau M.M., Jack L. The effectiveness of disease and case management for people with diabetes. A systematic review. Am J Prev Med. 2002;22:15–38. doi: 10.1016/s0749-3797(02)00423-3. [DOI] [PubMed] [Google Scholar]
  • 11.McAlister F.A., Lawson F.M., Teo K.K., Armstrong P.W. Randomised trials of secondary prevention programmes in coronary heart disease: systematic review. BMJ. 2001;323:957–962. doi: 10.1136/bmj.323.7319.957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12.Guevara J.P., Wolf F.M., Grum C.M., Clark N.M. Effects of educational interventions for self management of asthma in children and adolescents: systematic review and meta-analysis. BMJ. 2003;326:1308–1309. doi: 10.1136/bmj.326.7402.1308. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.McAlister F.A., Lawson F.M., Teo K.K., Armstrong P.W. A systematic review of randomized trials of disease management programs in heart failure. Am J Med. 2001;110:378–384. doi: 10.1016/s0002-9343(00)00743-9. [DOI] [PubMed] [Google Scholar]
  • 14.Weingarten S.R., Henning J.M., Badamgarav E., Knight K., Hasselblad V., Gano A., Jr Interventions used in disease management programmes for patients with chronic illness-which ones work? Meta-analysis of published reports. BMJ. 2002;325:925. doi: 10.1136/bmj.325.7370.925. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15.Bennett J.W., Glasziou P.P. Computerised reminders and feedback in medication management: a systematic review of randomized controlled trials. Med J Aust. 2003;178:217–222. doi: 10.5694/j.1326-5377.2003.tb05166.x. [DOI] [PubMed] [Google Scholar]
  • 16.Davis D.A., Taylor-Vaisey A., Translating guidelines into practice A systematic review of theoretic concepts, practical experience and research evidence in the adoption of clinical practice guidelines. CMAJ. 1997;157:408–416. [PMC free article] [PubMed] [Google Scholar]
  • 17.Wagner E.H., Austin B.T., Davis C., Hindmarsh M., Schaefer J., Bonomi A. Improving chronic illness care: translating evidence into action. Health Aff (Millwood) 2001;20:64–78. doi: 10.1377/hlthaff.20.6.64. [DOI] [PubMed] [Google Scholar]
  • 18.Roter D. The enduring and evolving nature of the patient-physician relationship. Patient Educ Couns. 2000;39:5–15. doi: 10.1016/s0738-3991(99)00086-5. [DOI] [PubMed] [Google Scholar]
  • 19.Greenfield S., Kaplan S., Ware J.E., Jr Expanding patient involvement in care. Effects on patient outcomes. Ann Intern Med. 1985;102:520–528. doi: 10.7326/0003-4819-102-4-520. [DOI] [PubMed] [Google Scholar]
  • 20.Greenfield S., Kaplan S.H., Ware J.E., Jr, Yano E.M., Frank H.J. Patients’ participation in medical care: effects on blood sugar control and quality of life in diabetes. J Gen Intern Med. 1988;3:448–457. doi: 10.1007/BF02595921. [DOI] [PubMed] [Google Scholar]
  • 21.Kaplan S.H., Gandek B., Greenfield S., Rogers W., Ware J.E. Patient and visit characteristics related to physicians’ participatory decision-making style. Results from the Medical Outcomes Study. Med Care. 1995;33:1176–1187. doi: 10.1097/00005650-199512000-00002. [DOI] [PubMed] [Google Scholar]
  • 22.The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus The Diabetes Control and Complications Trial Research Group. N Engl J Med. 1993;329:977–986. doi: 10.1056/NEJM199309303291401. [DOI] [PubMed] [Google Scholar]
  • 23.Bolanos E., Sarria-Santamera A. Perspective of patients on type-2 diabetes and their relationship with primary care health professionals: a qualitative study. Aten Primaria. 2003;32:195–200. doi: 10.1016/S0212-6567(03)79251-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24.Stewart M., Brown J.B., Donner A., McWhinney I.R., Oates J., Weston W.W. The impact of patient-centered care on outcomes. J Fam Pract. 2000;49:796–804. [PubMed] [Google Scholar]
  • 25.Bodenheimer T., Lorig K., Holman H., Grumbach K. Patient self-management of chronic disease in primary care. JAMA. 2002;288:2469–2475. doi: 10.1001/jama.288.19.2469. [DOI] [PubMed] [Google Scholar]
  • 26.Jolly K., Bradley F., Sharp S., Smith H., Thompson S., Kinmonth A.L. Randomised controlled trial of follow up care in general practice of patients with myocardial infarction and angina: final results of the Southampton heart integrated care project (SHIP). The SHIP Collaborative Group. BMJ. 1999;318:706–711. doi: 10.1136/bmj.318.7185.706. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Bradley F., Wiles R., Kinmonth A.L., Mant D., Gantley M. Development and evaluation of complex interventions in health services research: case study of the Southampton heart integrated care project (SHIP). The SHIP Collaborative Group. BMJ. 1999;318:711–715. doi: 10.1136/bmj.318.7185.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 28.Smith J. Redesigning health care. BMJ. 2001;322:1257–1258. doi: 10.1136/bmj.322.7297.1257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 29.Nyman M.A., Murphy M.E., Schryver P.G., Naessens J.M., Smith S.A. Improving performance in diabetes care: a multicomponent intervention. Eff Clin Pract. 2000;3:205–212. [PubMed] [Google Scholar]
  • 30.McCulloch D.K., Price M.J., Hindmarsh M., Wagner E.H. A population- based approach to diabetes management in a primary care setting: early results and lessons learned. Eff Clin Pract. 1998;1:12–22. [PubMed] [Google Scholar]
  • 31.Wagner E.H. Population-based management of diabetes care. Patient Educ Couns. 1995;26:225–230. doi: 10.1016/0738-3991(95)00761-n. [DOI] [PubMed] [Google Scholar]
  • 32.Herborg H., Soendergaard B., Froekjaer B., Fonnesbaek L., Jorgensen T., Hepler C.D. Improving drug therapy for patients with asthma. Part 1. Patient outcomes. J Am Pharm Assoc (Wash) 2001;41:539–550. doi: 10.1016/s1086-5802(16)31278-5. [DOI] [PubMed] [Google Scholar]
  • 33.Lukacs S.L., France E.K., Baron A.E., Crane L.A. Effectiveness of an asthma management program for pediatric members of a large health maintenance organization. Arch Pediatr Adolesc Med. 2002;156:872–876. doi: 10.1001/archpedi.156.9.872. [DOI] [PubMed] [Google Scholar]
  • 34.Shiffman R.N., Freudigman M., Brandt C.A., Liaw Y., Navedo D.D. A guideline implementation system using handheld computers for office management of asthma: effects on adherence and patient outcomes. Pediatrics. 2000;105:767–773. doi: 10.1542/peds.105.4.767. [DOI] [PubMed] [Google Scholar]
  • 35.Pinnock H., Bawden R., Proctor S., Wolfe S., Scullion J., Price D. Accessibility, acceptability, and effectiveness in primary care of routine telephone review of asthma: pragmatic, randomized controlled trial. BMJ. 2003;326:477–479. doi: 10.1136/bmj.326.7387.477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 36.Zorc J.J., Scarfone R.J., Li Y., Hong T., Harmelin M., Grunstein L. Scheduled follow-up after a pediatric emergency department visit for asthma: a randomized trial. Pediatrics. 2003;111:495–502. doi: 10.1542/peds.111.3.495. [DOI] [PubMed] [Google Scholar]
  • 37.Baren J.M., Shofer F.S., Ivey B., Reinhard S., DeGeus J., Stahmer S.A. A randomized, controlled trial of a simple emergency department intervention to improve the rate of primary care follow-up for patients with acute asthma exacerbations. Ann Emerg Med. 2001;38:115–122. doi: 10.1067/mem.2001.116593. [DOI] [PubMed] [Google Scholar]
  • 38.Turner M.O., Taylor D., Bennett R., Fitzgerald J.M. A randomized trial comparing peak expiratory flow and symptom self-management plans for patients with asthma attending a primary care clinic. Am J Respir Crit Care Med. 1998;157:540–546. doi: 10.1164/ajrccm.157.2.9703060. [DOI] [PubMed] [Google Scholar]
  • 39.Thoonen B.P., Schermer T.R., Van Den B.G., Molema J., Folgering H., Akkermans R.P. Self-management of asthma in general practice, asthma control and quality of life: a randomised controlled trial. Thorax. 2003;58:30–36. doi: 10.1136/thorax.58.1.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 40.Abdulwadud O., Abramson M., Forbes A., James A., Walters E.H. Evaluation of a randomised controlled trial of adult asthma education in a hospital setting. Thorax. 1999;54:493–500. doi: 10.1136/thx.54.6.493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 41.Homer C., Susskind O., Alpert H.R., Owusu M., Schneider L., Rappaport L.A. An evaluation of an innovative multimedia educational software program for asthma management: report of a randomized, controlled trial. Pediatrics. 2000;106:210–215. [PubMed] [Google Scholar]
  • 42.Eccles M., McColl E., Steen N., Rousseau N., Grimshaw J., Parkin D. Effect of computerised evidence based guidelines on management of asthma and angina in adults in primary care: cluster randomised controlled trial. BMJ. 2002;325:941. doi: 10.1136/bmj.325.7370.941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 43.Olivarius N.F., Beck-Nielsen H., Andreasen A.H., Horder M., Pedersen P.A. Randomised controlled trial of structured personal care of type 2 diabetes mellitus. BMJ. 2001;323:970–975. doi: 10.1136/bmj.323.7319.970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 44.Sikka R., Waters J., Moore W., Sutton D.R., Herman W.H., Aubert R.E. Renal assessment practices and the effect of nurse case management of health maintenance organization patients with diabetes. Diabetes Care. 1999;22:1–6. doi: 10.2337/diacare.22.1.1. [DOI] [PubMed] [Google Scholar]
  • 45.McDermott R.A., Schmidt B.A., Sinha A., Mills P. Improving diabetes care in the primary healthcare setting: a randomised cluster trial in remote Indigenous communities. Med J Aust. 2001;174:497–502. doi: 10.5694/j.1326-5377.2001.tb143397.x. [DOI] [PubMed] [Google Scholar]
  • 46.Montori V.M., Dinneen S.F., Gorman C.A., Zimmerman B.R., Rizza R.A., Bjornsen S.S. The impact of planned care and a diabetes electronic management system on community-based diabetes care: the Mayo Health System Diabetes Translation Project. Diabetes Care. 2002;25:1952–1957. doi: 10.2337/diacare.25.11.1952. [DOI] [PubMed] [Google Scholar]
  • 47.Clancy D.E., Brown S.B., Magruder K.M., Huang P. Group visits in medically and economically disadvantaged patients with type 2 diabetes and their relationships to clinical outcomes. Top Health Inf Manage. 2003;24:8–14. [PubMed] [Google Scholar]
  • 48.Goldhaber-Fiebert J.D., Goldhaber-Fiebert S.N., Tristan M.L., Nathan D.M. Randomized controlled community-based nutrition and exercise intervention improves glycemia and cardiovascular risk factors in type 2 diabetic patients in rural Costa Rica. Diabetes Care. 2003;26:24–29. doi: 10.2337/diacare.26.1.24. [DOI] [PubMed] [Google Scholar]
  • 49.Canga N., De Irala J., Vara E., Duaso M.J., Ferrer A., Martínez- González M.A. Intervention study for smoking cessation in diabetic patients: a randomized controlled trial in both clinical and primary care settings. Diabetes Care. 2000;23:1455–1460. doi: 10.2337/diacare.23.10.1455. [DOI] [PubMed] [Google Scholar]
  • 50.Wagner E.H., Grothaus L.C., Sandhu N., Galvin M.S., McGregor M., Artz K. Chronic care clinics for diabetes in primary care: a system-wide randomized trial. Diabetes Care. 2001;24:695–700. doi: 10.2337/diacare.24.4.695. [DOI] [PubMed] [Google Scholar]
  • 51.Sadur C.N., Moline N., Costa M., Michalik D., Mendlowitz D., Roller S. Diabetes management in a health maintenance organization. Efficacy of care management using cluster visits. Diabetes Care. 1999;22:2011–2017. doi: 10.2337/diacare.22.12.2011. [DOI] [PubMed] [Google Scholar]
  • 52.Piette J.D., Weinberger M., Kraemer F.B., McPhee S.J. Impact of automated calls with nurse follow-up on diabetes treatment outcomes in a Department of Veterans Affairs Health Care System: a randomized controlled trial. Diabetes Care. 2001;24:202–208. doi: 10.2337/diacare.24.2.202. [DOI] [PubMed] [Google Scholar]
  • 53.Piette J.D., Weinberger M., McPhee S.J. The effect of automated calls with telephone nurse follow-up on patient-centered outcomes of diabetes care: a randomized, controlled trial. Med Care. 2000;38:218–230. doi: 10.1097/00005650-200002000-00011. [DOI] [PubMed] [Google Scholar]
  • 54.Peters A.L., Davidson M.B. Application of a diabetes managed care program. The feasibility of using nurses and a computer system to provide effective care. Diabetes Care. 1998;21:1037–1043. doi: 10.2337/diacare.21.7.1037. [DOI] [PubMed] [Google Scholar]
  • 55.Thompson D.M., Kozak S.H., Sheps S. Insulin adjustment by a diabetes nurse educator improves glucose control in insulin-requiring diabetic patients: a randomized trial. CMAJ. 1999;161:959–962. [PMC free article] [PubMed] [Google Scholar]
  • 56.Frijling B.D., Lobo C.M., Hulscher M.E., Akkermans R.P., Braspenning J.C., Prins A. Multifaceted support to improve clinical decision making in diabetes care: a randomized controlled trial in general practice. Diabet Med. 2002;19:836–842. doi: 10.1046/j.1464-5491.2002.00810.x. [DOI] [PubMed] [Google Scholar]
  • 57.Pill R., Stott N.C., Rollnick S.R., Rees M. A randomized controlled trial of an intervention designed to improve the care given in general practice to type II diabetic patients: patient outcomes and professional ability to change behaviour. Fam Pract. 1998;15:229–235. doi: 10.1093/fampra/15.3.229. [DOI] [PubMed] [Google Scholar]
  • 58.Armalé M.J., Lozano M.L., Sánchez N.C. The education of type-2 diabetics: why not in groups? Aten Primaria. 1999;23:485–492. [PubMed] [Google Scholar]
  • 59.Kiefe C.I., Allison J.J., Williams O.D., Person S.D., Weaver M.T., Weissman N.W. Improving quality improvement using achievable benchmarks for physician feedback: a randomized controlled trial. JAMA. 2001;285:2871–2879. doi: 10.1001/jama.285.22.2871. [DOI] [PubMed] [Google Scholar]
  • 60.Kinmonth A.L., Woodcock A., Griffin S., Spiegal N., Campbell M.J. Randomised controlled trial of patient centred care of diabetes in general practice: impact on current wellbeing and future disease risk. The Diabetes Care From Diagnosis Research Team. BMJ. 1998;317:1202–1208. doi: 10.1136/bmj.317.7167.1202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 61.Dally D.L., Dahar W., Scott A., Roblin D., Khoury A.T. The impact of a health education program targeting patients with high visit rates in a managed care organization. Am J Health Promot. 2002;17:101–111. doi: 10.4278/0890-1171-17.2.101. [DOI] [PubMed] [Google Scholar]
  • 62.Peters A.L., Davidson M.B. Application of a diabetes managed care program. The feasibility of using nurses and a computer system to provide effective care. Diabetes Care. 1998;21:1037–1043. doi: 10.2337/diacare.21.7.1037. [DOI] [PubMed] [Google Scholar]
  • 63.Stroebel R.J., Broers J.K., Houle S.K., Scott C.G., Naessens J.M. Improving hypertension control: a team approach in a primary care setting. Jt Comm J Qual Improv. 2000;26:623–632. doi: 10.1016/s1070-3241(00)26053-7. [DOI] [PubMed] [Google Scholar]
  • 64.Zernike W., Henderson A. Evaluating the effectiveness of two teaching strategies for patients diagnosed with hypertension. J Clin Nurs. 1998;7:37–44. doi: 10.1046/j.1365-2702.1998.00128.x. [DOI] [PubMed] [Google Scholar]
  • 65.Rogers M.A., Small D., Buchan D.A., Butch C.A., Stewart C.M., Krenzer B.E. Home monitoring service improves mean arterial pressure in patients with essential hypertension. A randomized, controlled trial. Ann Intern Med. 2001;134:1024–1032. doi: 10.7326/0003-4819-134-11-200106050-00008. [DOI] [PubMed] [Google Scholar]
  • 66.Montgomery A.A., Fahey T., Peters T.J., MacIntosh C., Sharp D.J. Evaluation of computer based clinical decision support system and risk chart for management of hypertension in primary care: randomised controlled trial. BMJ. 2000;320:686–690. doi: 10.1136/bmj.320.7236.686. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 67.Dally D.L., Dahar W., Scott A., Roblin D., Khoury A.T. The impact of a health education program targeting patients with high visit rates in a managed care organization. Am J Health Promot. 2002;17:101–111. doi: 10.4278/0890-1171-17.2.101. [DOI] [PubMed] [Google Scholar]
  • 68.Kasper E.K., Gerstenblith G., Hefter G., Van Anden E., Brinker J.A., Thiemann D.R. A randomized trial of the efficacy of multidisciplinary care in heart failure outpatients at high risk of hospital readmission. J Am Coll Cardiol. 2002;39:471–480. doi: 10.1016/s0735-1097(01)01761-2. [DOI] [PubMed] [Google Scholar]
  • 69.Capomolla S., Febo O., Ceresa M., Caporotondi A., Guazzotti G., La Rovere M. Cost/utility ratio in chronic heart failure: comparison between heart failure management program delivered by day-hospital and usual care. J Am Coll Cardiol. 2002;40:1259–1266. doi: 10.1016/s0735-1097(02)02140-x. [DOI] [PubMed] [Google Scholar]
  • 70.Ekman I., Andersson B., Ehnfors M., Matejka G., Persson B., Fagerberg B. Feasibility of a nurse-monitored, outpatient-care programme for elderly patients with moderate-to-severe, chronic heart failure. Eur Heart J. 1998;19:1254–1260. doi: 10.1053/euhj.1998.1095. [DOI] [PubMed] [Google Scholar]

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