Table 2.
Signs and symptoms in relation to sex difference in patients with mastocytosis
| Organ involvement or symptom@ | yes | no | P$ univariate | P^multivariate |
|---|---|---|---|---|
| Skin involvement | ||||
| Male n (%) | 1087 (71&) | 452 (29) | 0.0001 | 0.0001 |
| Female n (%) | 1604 (86) | 262 (14) | ||
| Enlarged spleen | ||||
| Male n (%) | 249 (18) | 1161 (82) | <0.0001 | not tested |
| Female n (%) | 138 (8) | 1585 (92) | ||
| Enlarged liver | ||||
| Male n (%) | 224 (16) | 1181 (84) | <0.0001 | not tested |
| Female n (%) | 140 (8) | 1581 (92) | ||
| Enlarged lymph nodes | ||||
| Male n (%) | 125 (6) | 1189 (90) | <0.0001 | not tested |
| Female n (%) | 86 (5) | 1537 (95) | ||
| Organomegaly# | ||||
| Male n (%) | 335 (23) | 1092 (77) | <0.0001 | <0.0001 |
| Female n (%) | 217 (13) | 1514 (87) | ||
| Skin symptoms including flushes | ||||
| Male n (%) | 851 (58) | 612 (42) | <0.0001 | <0.0001 |
| Female n (%) | 1370 (76) | 436 (24) | ||
| Anaphylaxis | ||||
| Male n (%) | 309 (22) | 1101 (78) | 0.240 | 0.232 |
| Female n (%) | 403 (24) | 1292 (76) | ||
| Bone signs and symptoms (pain, osteoporosis, osteopenia) | ||||
| Male n (%) | 430 (34) | 820 (66) | 0.232 | 0.788 |
| Female n (%) | 563 (37) | 969 (63) | ||
| Gastrointestinal symptoms | ||||
| Male n (%) | 446 (31) | 983 (69) | <0.0001 | <0.0001 |
| Female n (%) | 767 (44) | 987 (56) | ||
| Headache | ||||
| Male n (%) | 121 (8) | 1418 (92) | <0.0001 | 0.001 |
| Female n (%) | 291 (16) | 1575 (84) | ||
| Allergy | ||||
| Male n (%) | 418 (34) | 829 (66) | 0.436 | 0.662 |
| Female n (%) | 475 (32) | 1004 (68) | ||
@ Signs and symptoms were not documented in all patients
# Any of the three: enlarged spleen, liver or lymph nodes
& Percentages were rounded-up to enhance clarity
$ P-value assessed by univariate (Fischer exact test) and ^multinominal logistic regression including the WHO subcategory.