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. 2013 Apr 5;31(6):361–365. [Article in Spanish] doi: 10.1016/S0212-6567(03)70699-4

Empleo de antiagregantes en la prevención primaria y secundaria cardiovascular del diabético en el medio urbano y rural del área de León

Use of Anti-Aggregant Drugs in Primary and Secondary Cardiovascular Prevention in Diabetics in town and Country in the León Area

J López de la Iglesia a,*, S Escudero Álvarez a, AM González García a, A Mencía Mieres a, LE García Andrés b, B Morán Fernández c
PMCID: PMC7681639  PMID: 12716570

Abstract

Objectives

To find how many diabetics should receive anti-aggregant treatment according to the recommendations made since 2001 by the American Diabetes Association (ADA), how many cardiovascular events could be avoided by 100 mg daily of acetylsalicylic acid (ASA), and the cost per event avoided by this measure.

Design

Transversal, descriptive, multi-centre study.

Setting

Primary care. 8 clinics in 5 health districts (3 rural, 1 semi-urban, 4 urban) in the León area.

Participants

Diabetics aged 14 or over diagnosed through the ADA criteria since 1997.

Main measurements

Audit of clinical records, collecting age and sex, the presence of the criteria of the ADA for anti-aggregation, the existence of established cardiovascular disease (CVD) and the anti-aggregant treatment patients receive.

Results

544 diabetics. 97.2% (95% CI, 95.8%-98.6%) comply with anti-aggregation criteria. 101 had established CVD (18.6%; CI, 15.3%-21.9%); 77.2% received antiaggregants (CI, 73.7%-80.7%). 428 had no CVD and did have antiaggregation criteria (78.7%; CI, 75.3%- 82.1%); 9.3% (CI, 6.9%-11.7%) received treatment.

Conclusions

There was basically little followup of the ADA anti-aggregation recommendations in primary prevention.

Treatment of our diabetics with 100 mg/day of ASA would avoid 7.64 cardiovascular events in five years (CI, 5.56-9.72). The cost per cardiovascular event avoided was 6,625.37 euros (CI, 4821.60-8429.14 euros).

Key words: Diabetes, Anti-aggregants, Efficiency, Primary care

Footnotes

Premio Mejor Comunicación PAPPS-SCLMFyC. II Congreso de Atención Primaria de Castilla y León (Segovia, abril de 2002).

Bibliografía

  • 1.Haffner S.M., Lehto S., Ronnemaa T., Pyorala K., Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 1998;339:229–234. doi: 10.1056/NEJM199807233390404. [DOI] [PubMed] [Google Scholar]
  • 2.Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III) JAMA. 2001;285:2486–2497. doi: 10.1001/jama.285.19.2486. [DOI] [PubMed] [Google Scholar]
  • 3.Evans J.M., Wang J., Morris A.D. Comparison of cardiovascular risk between patients with type 2 diabetes and those who had had a myocardial infarction: cross sectional and cohort studies. BMJ. 2002;324:939–943. doi: 10.1136/bmj.324.7343.939. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Levin R.D., Kwaan H.C., Dobbie J.G., Fetkenhour C.L., Traisman H.S. Partial purification and studies of the plasma co-factor that potentiates platelet aggregation in diabetes mellitus. J Lab Clin Med. 1981;98:519–526. [PubMed] [Google Scholar]
  • 5.Collaborative overview of randomised trials of antiplatelet therapy- I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients Antiplatelet Trialists’ Collaboration. BMJ. 1994;308:81–106. [PMC free article] [PubMed] [Google Scholar]
  • 6.Hennekens C.H., Dyken J.L., Fuster V. Aspirin as a therapeutic agent in cardiovascular disease. A statement for Healthcare Professionals from the American Heart Association. Circulation. 1997;96:2751–2753. doi: 10.1161/01.cir.96.8.2751. [DOI] [PubMed] [Google Scholar]
  • 7.Ryan T.J., Anderson J.L., Antman E.M., Braniff B.A., Brooks N.H., Califf R.M. ACC/AHA Guidelines for the management of patients with acute myocardial infarction. J Am Coll Cardiol. 1996;28:1328–1428. doi: 10.1016/s0735-1097(96)00392-0. [DOI] [PubMed] [Google Scholar]
  • 8.Prevention of coronary heart disease in clinical practice Recommendations of the Second Joint Task Force of European and other Societies on Coronary Prevention. Eur Heart J. 1998;19:1434–1503. doi: 10.1053/euhj.1998.1243. [DOI] [PubMed] [Google Scholar]
  • 9.Arós F., Loma-Osorio A., Alonso A., Alonso J.J., Cabadés A., Coma- Canella I. Guías de actuación clínica de la Sociedad Española de Cardiología en el infarto agudo de miocardio. Rev Esp Cardiol. 1999;52:919–956. doi: 10.1016/s0300-8932(99)75024-4. [DOI] [PubMed] [Google Scholar]
  • 10.Hirsh J., Dalen J.E., Guyatt G. The Sixth ACCP Guidelines for Antithrombotic Therapy for Prevention and Treatment of Trombosis. Chest. 2000;119:1S–2S. doi: 10.1378/chest.119.1_suppl.1s. [DOI] [PubMed] [Google Scholar]
  • 11.Steering Committee of the Physicians’ Health Study Research Group Final report on the aspirin component of the ongoing Physicians’ Health Study. N Engl J Med. 1989;321:129–135. doi: 10.1056/NEJM198907203210301. [DOI] [PubMed] [Google Scholar]
  • 12.Sanmuganathan P.S., Ghahramani P., Jackson P.R., Wallis E.J., Ramsay L.E. Aspirin for primary prevention of coronary heart disease: safety and absolute benefit related to coronary risk derived from meta-analysis of randomised trials. Heart. 2001;85:265–271. doi: 10.1136/heart.85.3.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.Hayden M., Pignone M., Phillips C., Mulrow C. Aspirin for the primary prevention of cardiovascular events: a summary of the evidence for the US Preventive Services Task Force. Ann Intern Med. 2002;136:161–172. doi: 10.7326/0003-4819-136-2-200201150-00016. [DOI] [PubMed] [Google Scholar]
  • 14.American Diabetes Association Aspirin therapy in diabetes. Position statement. Diabetes Care. 2001;24:S76–S77. [Google Scholar]
  • 15.American Diabetes Association Aspirin therapy in diabetes. Position statement. Diabetes Care. 2002;25:S78–S79. [Google Scholar]
  • 16.Rolka D.B., Fagot-Campagna A., Narayan K.M. Aspirin use among adults with diabetes: estimates from the Third National Health and Nutrition Examination Survey. Diabetes Care. 2001;24:197–201. doi: 10.2337/diacare.24.2.197. [DOI] [PubMed] [Google Scholar]
  • 17.Tamayo-Marco B., Faure-Nogueras E., Roche-Asensio M.J., Rubio- Calvo E., Sánchez-Oriz E., Salvador-Olivan J.A. Prevalence of diabetes and impaired glucose tolerance in Aragon. Spain. Diabetes Care. 1997;20:534–536. doi: 10.2337/diacare.20.4.534. [DOI] [PubMed] [Google Scholar]

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