Abstract
Objetivo
Estudiar el riesgo cardiovascular (RCV) asociado a las categorías diagnósticas de la diabetes propuestas por la Asociación Americana de Diabetes.
Diseño
Estudio descriptivo, transversal.
Emplazamiento
Área básica de salud (ABS) urbana.
Pacientes
Se estudiaron 1.840 pacientes 3 15 años, seleccionados por muestreo aleatorio simple del archivo de historias clínicas (HC).
Método
Mediante revisión de la HC se clasificó a los pacientes en normoglucemia, glucemia basal alterada (GBA) y diabetes mellitus tipo 2 (DM2). Se estudió el RCV mediante el método de Framingham simplificado y los factores de RCV obesidad, tabaquismo, hipertensión arterial, hipercolesterolemia y hipertrigliceridemia. La probabilidad de tener un RCV elevado o muy elevado y los factores de RCV descritos en los pacientes con GBA y DM2 respecto a los normoglucémicos se estudiaron mediante regresión logística, ajustando la odds ratio (OR) por edad y sexo.
Resultados
Se clasificó a 1.351 pacientes: 995 normoglucémicos, 146 pacientes GBA y 210 pacientes DM2. Los pacientes con GBA y DM2 tuvieron una probabilidad superior de presentar un RCV elevado o muy elevado, con unas OR de 2,26 (IC del 95%, 1,39–3,69) y 2,74 (IC del 95%, 1,81–4,15), respectivamente. También presentaron diferencias (p < 0,05) respecto a la obesidad (OR, 1,76 y 1,58, respectivamente), hipertensión arterial (OR, 1,75 y 2,15, respectivamente) e hipertrigliceridemia (OR, 1,73 y 2,70, respectivamente), sin diferencias (p > 0,05) respecto al tabaquismo y la hipercolesterolemia. No se detectaron diferencias (p > 0,05) entre GBA y DM2 respecto al RVC y los factores de RCV estudiados.
Conclusiones
Los pacientes con GBA y DM2 tienen un elevado RCV.
Palabras clave: Diabetes mellitus, Glucemia basal alterada, Intolerancia a la glucose, Riesgo cardiovascular, Atención primaria
Abstract
Objective
To study the cardiovascular risk (CVR) associated with the diagnostic criteria for diabetes proposed by the American Diabetes Association.
Design
Cross-sectional, descriptive study.
Setting
Urban health district.
Patients
1840 patients > 14 years old, selected by simple randomised sampling from the clinical records (CR) archive, were studied.
Method
Through review of the CR, the patients were classified as having: normal glycaemia, disturbed basal glycaemia (DBG) and type-2 diabetes mellitus (DM2). CVR was studied through the simplified Framingham method and the CVR factors of obesity, tobacco dependency, hypertension, hypercholesterolaemia and hypertriglyceridaemia. The likelihood of having high or very high CVR and the CVR factors described in the patients with DBG or DM2 were compared with the same in those with normal glycaemia, through logistical regression with the odds ratio adjusted for age and sex.
Results
1351 patients were classified: 995 with normal glycaemia, 146 with DBG and 210 with DM2. Patients with DBG or DM2 had greater likelihood of high or very high CVR, with some OR at 2.26 (95% CI, 1.39–3.69) and 2.74 (95% CI, 1.81–4.15), respectively. They also had differences (p < 0.05) for obesity (OR, 1.76 and 1.58), hypertension (OR, 1.75 and 2.15) and hypertriglyceridaemia (OR, 1.73 and 2.70), respectively. There were no differences (p > 0.05) for tobacco dependency and hypercholesterolaemia. No differences were found (p > 0.05) between DBG and DM2 for CVR and the CVR factors studied.
Conclusions
Patients with DBG and DM2 are at high CVR.
Key words: Diabetes mellitus, Disturbed basal glycaemia, Glucose intolerance, Cardiovascular risk, Primary care
Bibliografía
- 1.The Expert Committee on the diagnosis and Classification of Diabetes Mellitus Report of the Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997;20:1183–1197. doi: 10.2337/diacare.20.7.1183. [DOI] [PubMed] [Google Scholar]
- 2.World Health Organization . Report of a WHO Study Group. Technical report series n.o 727. OMS; Ginebra: 1985. Diabetes mellitus. [Google Scholar]
- 3.Alberti K.G.M.M., Zimmet P.Z., for the WHO Consultation Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of WHO consultation. Diabetes Med. 1998;15:539–553. doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S. [DOI] [PubMed] [Google Scholar]
- 4.Baena Díez J.M., Oller Colom M., Martín Peñacoba R., Nicolau Sabaté M., Altes Boronat A., Iglesis Serrano C. Impacto de los nuevos criterios diagnósticos propuestos por la Asociación Americana de Diabetes (ADA-97) sobre la prevalencia diagnóstica de diabetes mellitus tipo 2. Aten Primaria. 1999;24:97–100. [PubMed] [Google Scholar]
- 5.UKPDS Group Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patiens with type 2 diabetes (UKPDS 33) Lancet. 1998;352:837–852. [PubMed] [Google Scholar]
- 6.Muñiz J., Cordido F., López Rodríguez I., Castro Beiras A. Effect of the application of the new diagnostic criteria of diabetes mellitus in the prevalence estimates and diagnostic level in the general population. Eur J Pub Health. 1999;9:149–151. [Google Scholar]
- 7.Donahue R.P., Orchard T.J. Diabetes mellitus and macrovascular complications. Diabetes Care. 1992;15:1141–1155. doi: 10.2337/diacare.15.9.1141. [DOI] [PubMed] [Google Scholar]
- 8.Stamler J., Vaccaro O., Neaton J.D., Wentworth D. Diabetes, other risk factors, and 12-year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care. 1993;16:434–444. doi: 10.2337/diacare.16.2.434. [DOI] [PubMed] [Google Scholar]
- 9.Wingard D.L., Scheidt-Nave C., Barret-Connor E.L., McPhillips J.B. Prevalence of cardiovascular and renal complications in older adults with normal or impaired glucose tolerance or NIDDM. Diabetes Care. 1993;16:1022–1025. doi: 10.2337/diacare.16.7.1022. [DOI] [PubMed] [Google Scholar]
- 10.Gerstein H.C. Is glucose a continous risk factor for cardiovascular mortality? Diabetes Care. 1999;22:659–660. doi: 10.2337/diacare.22.5.659. [DOI] [PubMed] [Google Scholar]
- 11.Meigs J.B., Nathan D.M., Wilson P.W., Cupples L.A., Singer D.E. Metabolic risk factors worsen continously across the spectrum of nondiabetic glucose tolerance. The Framingham Offspring Study. Ann Intern Med. 1998;128:524–533. doi: 10.7326/0003-4819-128-7-199804010-00002. [DOI] [PubMed] [Google Scholar]
- 12.Gerstein H.C., Pais P., Pogue J., Yusuf S. Relationship of glucose and insulin levels to the risk of myocardial infarction: a case-control study. J Am Coll Cardiol. 1999;33:612–619. doi: 10.1016/s0735-1097(98)00637-8. [DOI] [PubMed] [Google Scholar]
- 13.Coutinho M., Wang Y., Gerstein H.C., Yusuf S. The relationship between glucose and incident cardiovascular events. Diabetes Care. 1999;22:233–240. doi: 10.2337/diacare.22.2.233. [DOI] [PubMed] [Google Scholar]
- 14.Keen H. Impacto de los nuevos criterios de diabetes sobre el patrón de la enfermedad. Lancet (ed. esp.) 1999;34:63–64. [Google Scholar]
- 15.Costa B., Martín F., Donado A., Parera F., Piñol J.L., Basora J. Diabetes ignorada y otras alteraciones del metabolismo glucídico en la población española de alto riesgo. El studio ITG. Med Clin (Barc) 2000;114:601–608. doi: 10.1016/s0025-7753(00)71376-5. [DOI] [PubMed] [Google Scholar]
- 16.Costa B. ¿Cómo diagnosticaremos en España la diabetes más allá del año 2000? Med Clin (Barc) 1999;112:572–574. [PubMed] [Google Scholar]
- 17.Programa de Actividades Preventivas y de Promoción de la Salud . Guía de prevención cardiovascular. Sociedad Española de Medicina de Familia y Comunitaria; Madrid: 1996. [Google Scholar]
- 18.Sociedad Española de Medicina de Familia y Comunitaria . Programas básicos de salud. Diabetes mellitus. Doyma; Madrid: 1998. [Google Scholar]
- 19.Córdoba García R., Ortega Sánchez-Pinilla R., Cabezas Peña C., Forés García D., Nebot Adell M. Recomendaciones sobre el estilo de vida. Aten Primaria. 1999;24(Supl 1):118–132. [PubMed] [Google Scholar]
- 20.Anderson K., Wilson P., Odell P., Kannel W. An updated coronary risk profile. Circulation. 1991;83:356–362. doi: 10.1161/01.cir.83.1.356. [DOI] [PubMed] [Google Scholar]
- 21.Marrugat J., Vila J., Pavesi P., Sanz F. Estimación del tamaño de la muestra en la investigación clínica y epidemiológica. Med Clin (Barc) 1998;111:267–276. [PubMed] [Google Scholar]
- 22.Fontbonne A., Eschwège E., Cambien F., Richard J.L., Ducimetière P., Thibult N. Hypertriglyceridaemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes: results from 11-year follow-up of the Paris Prospective Study. Diabetología. 1989;32:300–304. doi: 10.1007/BF00265546. [DOI] [PubMed] [Google Scholar]
- 23.Laakso M., Letho P., Penttilä I., Pyörälä K. Lipids and lipoproteins predicting coronary heart disease mortality and morbidity in patiens with non-insulin-dependent diabetes. Circulation. 1993;88:1421–1430. doi: 10.1161/01.cir.88.4.1421. [DOI] [PubMed] [Google Scholar]
- 24.American Diabetes Association Manegement of dyslipidemia in adults with diabetes. Diabetes Care. 1998;21(Supl 1):36–39. doi: 10.2337/diacare.21.1.179. [DOI] [PubMed] [Google Scholar]
- 25.Psaty B.M., Nicholas L.S., Siscovick D.S., Koepsell T.D., Weiss N.S., Heckbert S.R. Health outcomes associated with antihypertensive therapies used as first-line agents. JAMA. 1997;277:739–745. [PubMed] [Google Scholar]
- 26.The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment oh High Blood Pressure. National Institute of Health: National Heart, Lung, and Blood Institute; Bethesda: 1997. [Google Scholar]
- 27.UK Prospective Diabetes Study Group Tight blood pressure control and risk of macrovascular and micro-vascular complications in type 2 diabetes: UKPDS 38. BMJ. 1998;317:703–713. [PMC free article] [PubMed] [Google Scholar]
- 28.GEDAPS . Guía para el tratamiento de la diabetes tipo 2 en la Atención Primaria. Harcourt; Madrid: 1999. [Google Scholar]
- 29.Ming W., Haffner S.M., Gaskill S.P., Stern M.P. Effects of diabetes and level of glycemia on all-cause and cardiovascular mortality. Diabetes Care. 1998;21:1167–1171. doi: 10.2337/diacare.21.7.1167. [DOI] [PubMed] [Google Scholar]
- 30.Tominaga M., Igarashi K., Eguchi H., Kato T., Manaka H., Sekikawa A. Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. Diabetes Care. 1999;22:920–924. doi: 10.2337/diacare.22.6.920. [DOI] [PubMed] [Google Scholar]
- 31.Wilson P.W., Cupples L.A., Kannel W.B. Is hyperglicemia associated with cardiovascular disease? The Framingham Study. Am Heart J. 1991;121:586–590. doi: 10.1016/0002-8703(91)90729-2. [DOI] [PubMed] [Google Scholar]
