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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Neuroscience. 2020 Jan 23;443:188–205. doi: 10.1016/j.neuroscience.2020.01.020

Table 5:

Effects of CCL2 ICV injection on mRNA expression in NEP+mHYP and LH of embryo brain

NEP+mHYP Female
 Male
mRNA No-ICV Control ICV Control ICV CCL2 No-ICV Control ICV Control ICV CCL2
CCL2 6.2E-4 ± 3.1E-5 6.9E-4 ± 3.7E-5 9.8E-4 ± 8.7E-5*# 5.4E-4 ± 3.8E-5 6.1E-4 ± 4.3E-5 4.7E-4 ± 5.0E-5*
CCR2 3.3E-3 ± 1.9E-4 3.0E-3 ± 1.3E-4 4.9E-3 ± 2.2E-4*# 2.4E-3 ± 1.6E-4 2.6E-3 ± 1.7E-4 3.0E-3 ± 3.9E-4*
BLBP 5.6E-2 ± 3.2E-3 5.7E-2 ± 5.0E-3 8.2E-2 ± 4.5E-3* 4.5E-2 ± 1.6E-3 4.8E-2 ± 1.3E-3 6.4E-2 ± 3.8E-3
MCH 6.6E-4 ± 3.9E-5 7.1E-4 ± 1.1E-5 1.1E-3 ± 6.1E-5* 6.8E-4 ± 4.3E-5 7.2E-4 ± 3.2E-5 8.6E-4 ± 4.9E-5
LH Female
 Male
mRNA No-ICV Control ICV Control ICV CCL2 No-ICV Control ICV Control ICV CCL2
CCL2 6.8E-4 ± 4.7E-5 7.1E-4 ± 4.6E-5 1.2E-3 ± 5.0E-5*# 7.1E-4 ± 6.0E-5 7.2E-4 ± 6.3E-5 8.2E-4 ± 4.6E-5*
CCR2 2.4E-3 ± 1.4E-4 2.5E-3 ± 1.5E-4 4.0E-3 ± 3.3E-4*# 2.5E-3 ± 2.9E-4 2.6E-3 ±1.7E-4 2.8E-3 ± 9.8E-5*
MCH 7.5E-3 ± 4.1E-4 7.5E-3 ± 3.9E-4 1.5E-2 ± 9.7E-4*# 7.5E-3 ± 3.2E-4 6.91E-3 ± 5.0E-4 9.6E-3 ± 3.3E-4*

Abbreviations: LH, lateral hypothalamus; NEP, neuroepithelium; mHYP, medial hypothalamus; CCL2, C-C motif ligand 2;

CCR2, C-C motif receptor 2; BLBP, brain lipid-binding protein, marker for radial glia; MCH, melanin-concentrating hormone;

ICV, intracerebroventricular