Figure 4. Hippocampal malrotation and relationship to morphology.

(A) Gaussian curvature of the hippocampal main axis computed across 18 equidistant points are color-coded with respect to the effect size of changes between patients and controls, showing marked bending in patients, particularly at the level of hippocampal tail. (B) Scatterplot shows a positive correlation between hippocampal curvature and clusters of increased cortical complexity in patients (r = 0.50, p < 0.001) but not in healthy controls. PVNH = periventricular nodular heterotopia.