Table 3. Details of all statistical tests N indicates biological replicates for example individual cells or behavior trials.
| Figure | Data | Test | P val | WT Animals | Het Animals | WT n | Het n |
|---|---|---|---|---|---|---|---|
| Figure 1C | Zone occupancy | Wilcoxon rank sum | 0.003 | 18 | 27 | ||
| Figure 1D | EPM Distance | Wilcoxon rank sum | 0.35 | 16 | 23 | ||
| Figure 1E | Open time | Wilcoxon rank sum | 0.001 | 18 | 27 | ||
| Figure 1E | Center time | Wilcoxon rank sum | 0.02 | 18 | 27 | ||
| Figure 1F | Head dips | Wilcoxon rank sum | 0.03 | 14 | 14 | ||
| Figure 1G | Open entries | Wilcoxon rank sum | 0.32 | 16 | 23 | ||
| Figure 1H | Open visit | Wilcoxon rank sum | 0.047 | 16 | 23 | ||
| Figure 2B | WPLI, t = 0 | Wilcoxon rank sum | 0.0007 | 6 | 7 | 274 | 316 |
| Figure 2B | WPLI, t = 1.5 | Wilcoxon rank sum | 0.043 | 6 | 7 | 274 | 316 |
| Figure 2B | WPLI, t = −3,–1.5, 0, +1.5 during closed-center runs |
Linear mixed effects model timepoint mouse genotype timept X genotype | 0.0026 0.47 0.059 0.0004 |
6 | 7 | 274 | 316 |
| Figure 2C | Avg zone WPLI, genotype | Two-way ANOVA | 0.03 | 6 | 7 | ||
| Figure 2C | Avg zone WPLI, zone | Two-way ANOVA | 0.063 | 6 | 7 | ||
| Figure 2C | Avg zone WPLI, interaction | Two-way ANOVA | 0.98 | 6 | 7 | ||
| Figure 2D | Theta WPLI | Wilcoxon rank sum | 0.031 | 6 | 7 | ||
| Figure 3E | IC zone projection, t = 0 | Wilcoxon rank sum | 0.007 | 6 | 7 | 39 | 37 |
| Figure 3E | ICA zone projection t = 0 vs. baseline (average of first and last timepoints) during closed-center-open runs | Linear mixed effects model timepoint mouse genotype timept X genotype | 0.085 0.16 0.0044 0.010 |
6 | 7 | 39 | 37 |
| Figure 4E | FSIN charge | Wilcoxon rank sum | 0.006 | 6 | 3 | 11 | 7 |
| Figure 4F | FSIN PPR | Wilcoxon rank sum | 0.03 | 6 | 3 | 11 | 7 |
| Figure 4G | FSIN latency | Wilcoxon rank sum | 0.013 | 6 | 3 | 11 | 7 |
| Figure 4H | FSIN # spikes | Wilcoxon rank sum | 0.08 | 6 | 3 | 11 | 7 |
| Figure 5E | Pyr charge | Wilcoxon rank sum | 0.28 | 13 | 8 | 17 | 11 |
| Figure 5F | Pyr PPR | Wilcoxon rank sum | 0.15 | 13 | 8 | 17 | 11 |
| Figure 5G | Pyr latency | Wilcoxon rank sum | 0.76 | 13 | 8 | 17 | 11 |
| Figure 5H | Pyr # spikes | Wilcoxon rank sum | 0.78 | 13 | 8 | 17 | 11 |
| Figure 1—figure supplement 1 | Sex-corrected zone occupancy | Wilcoxon rank sum | 0.013 | 18 | 27 | ||
| Figure 1—figure supplement 1A | Zone occupancy for Het M vs. F | Wilcoxon rank sum | 0.60 | M: 10, F: 17 | |||
| Figure 1—figure supplement 1B | Sex-corrected EPM distance | Wilcoxon rank sum | 0.79 | 16 | 23 | ||
| Figure 1—figure supplement 1C | Head dips: genotype | 2-way ANOVA | 0.02 | M: 10, F: 4 | M: 8, F: 6 | ||
| Figure 1—figure supplement 1C | Head dips: sex | 2-way ANOVA | 0.81 | M: 10, F: 4 | M: 8, F: 6 | ||
| Figure 1—figure supplement 1C | Head dips: genotype X sex | 2-way ANOVA | 0.36 | M: 10, F: 4 | M: 8, F: 6 | ||
| Figure 1—figure supplement 1C | Head dips for Het M vs. F | Wilcoxon rank sum | 0.54 | M: 8, F: 6 | |||
| Figure 1—figure supplement 1D | Open arm entries: genotype | 2-way ANOVA | 0.22 | M: 12, F: 4 | M: 9, F: 14 | ||
| Figure 1—figure supplement 1D | Open arm entries: sex | 2-way ANOVA | 0.61 | M: 12, F: 4 | M: 9, F: 14 | ||
| Figure 1—figure supplement 1D | Open entries: genotype X sex | 2-way ANOVA | 0.32 | M: 12, F: 4 | M: 9, F: 14 | ||
| Figure 1—figure supplement 1E | Open visit length: genotype | 2-way ANOVA | 0.22 | M: 12, F: 4 | M: 9, F: 14 | ||
| Figure 1—figure supplement 1E | Open visit length: sex | 2-way ANOVA | 0.49 | M: 12, F: 4 | M: 9, F: 14 | ||
| Figure 1—figure supplement 1E | Open visit length: genotype X sex | 2-way ANOVA | 0.76 | M: 12, F: 4 | M: 9, F: 14 | ||
| Figure 1—figure supplement 1F | Sex-corrected open arm time | Wilcoxon rank sum | 0.013 | 16 | 23 | ||
| Figure 1—figure supplement 1F | Open arm time: Het M vs. F | Wilcoxon rank sum | 0.61 | M: 10, F: 17 | |||
| Figure 1—figure supplement 1G | Center time: genotype | 2-way ANOVA | 0.087 | M: 12, F: 6 | M: 10, F: 17 | ||
| Figure 1—figure supplement 1G | Center time: sex | 2-way ANOVA | 0.29 | M: 12, F: 6 | M: 10, F: 17 | ||
| Figure 1—figure supplement 1G | Center time: genotype X sex | 2-way ANOVA | 0.48 | M: 12, F: 6 | M: 10, F: 17 | ||
| Figure 1—figure supplement 2A | Social interaction | Wilcoxon rank sum | 0.34 | 7 | 7 | ||
| Figure 1—figure supplement 2B | Novel objection | Wilcoxon rank sum | 0.95 | 7 | 7 | ||
| Figure 1—figure supplement 2C | Marble burying | Wilcoxon rank sum | 0.45 | 8 | 7 | ||
| Figure 1—figure supplement 2D | OF distance | Wilcoxon rank sum | 0.15 | 14 | 17 | ||
| Figure 1—figure supplement 2F | T-maze trials | Wilcoxon rank sum | 0.6 | 5 | 5 | ||
| Figure 1—figure supplement 2H | Rule shift IA | Wilcoxon rank sum | 0.89 | 4 | 4 | ||
| Figure 1—figure supplement 2H | Rule shift RS | Wilcoxon rank sum | 0.89 | 4 | 4 | ||
| Figure 2—figure supplement 1A | PFC theta power | Wilcoxon rank sum | 0.91 | 6 | 7 | ||
| Figure 2—figure supplement 1A | PFC beta power | Wilcoxon rank sum | 0.94 | 6 | 7 | ||
| Figure 2—figure supplement 1A | PFC low gamma power | Wilcoxon rank sum | 0.47 | 6 | 7 | ||
| Figure 2—figure supplement 1A | PFC high gamma power | Wilcoxon rank sum | 0.8 | 6 | 7 | ||
| Figure 2—figure supplement 1B | HPC Theta power | Wilcoxon rank sum | 0.23 | 6 | 7 | ||
| Figure 2—figure supplement 1B | HPC Beta power | Wilcoxon rank sum | 0.093 | 6 | 7 | ||
| Figure 2—figure supplement 1B | HPC low gamma power | Wilcoxon rank sum | 0.17 | 6 | 7 | ||
| Figure 2—figure supplement 1B | HPC high gamma power | Wilcoxon rank sum | 0.94 | 6 | 7 | ||
| Figure 2—figure supplement 1C | PFC closed theta power | Wilcoxon rank sum | 0.88 | 6 | 7 | ||
| Figure 2—figure supplement 1C | PFC closed beta power | Wilcoxon rank sum | 1 | 6 | 7 | ||
| Figure 2—figure supplement 1C | PFC closed LG power | Wilcoxon rank sum | 0.29 | 6 | 7 | ||
| Figure 2—figure supplement 1C | PFC closed HG power | Wilcoxon rank sum | 0.1 | 6 | 7 | ||
| Figure 2—figure supplement 1D | HPC closed theta power | Wilcoxon rank sum | 0.25 | 6 | 7 | ||
| Figure 2—figure supplement 1D | HPC closed beta power | Wilcoxon rank sum | 0.15 | 6 | 7 | ||
| Figure 2—figure supplement 1D | HPC closed LG power | Wilcoxon rank sum | 0.48 | 6 | 7 | ||
| Figure 2—figure supplement 1D | HPC closed HG power | Wilcoxon rank sum | 0.89 | 6 | 7 | ||
| Figure 2—figure supplement 1E | PFC open theta power | Wilcoxon rank sum | 0.89 | 6 | 7 | ||
| Figure 2—figure supplement 1E | PFC open beta power | Wilcoxon rank sum | 0.89 | 6 | 7 | ||
| Figure 2—figure supplement 1E | PFC open LG power | Wilcoxon rank sum | 1 | 6 | 7 | ||
| Figure 2—figure supplement 1E | PFC open HG power | Wilcoxon rank sum | 0.15 | 6 | 7 | ||
| Figure 2—figure supplement 1F | HPC open theta power | Wilcoxon rank sum | 0.32 | 6 | 7 | ||
| Figure 2—figure supplement 1F | HPC open beta power | Wilcoxon rank sum | 0.2 | 6 | 7 | ||
| Figure 2—figure supplement 1F | HPC open LG power | Wilcoxon rank sum | 0.25 | 6 | 7 | ||
| Figure 2—figure supplement 1F | HPC open HG power | Wilcoxon rank sum | 1 | 6 | 7 | ||
| Figure 3—figure supplement 1D | IC #1 zone projection | Wilcoxon rank sum | 0.007 | 6 | 7 | 39 | 37 |
| Figure 3—figure supplement 1D | IC #1 zone projection t = 0 vs. baseline (average of first and last timepoints) during closed-center-open runs | Linear mixed effects model timepoint mouse genotype timept X genotype | 0.085 0.16 0.0044 0.010 |
6 | 7 | 39 | 37 |
| Figure 3—figure supplement 1F | IC #3 zone projection | Wilcoxon rank sum | 0.015 | 6 | 7 | 39 | 37 |
| Figure 3—figure supplement 1F | IC #3 zone projection t = 0 vs. baseline (average of first and last timepoints) during closed-center-open runs | Linear mixed effects model timepoint mouse genotype timept X genotype | 0.0094 0.50 0.026 0.052 |
6 | 7 | 39 | 37 |
| Figure 4—figure supplement 1C | FSIN resting potential | Wilcoxon rank sum | 0.50 | 6 | 3 | 11 | 7 |
| Figure 4—figure supplement 1D | FSIN input resistance | Wilcoxon rank sum | 0.44 | 6 | 3 | 11 | 7 |
| Figure 4—figure supplement 1E | FSIN halfwidth | Wilcoxon rank sum | 0.47 | 6 | 3 | 11 | 7 |
| Figure 4—figure supplement 1F | FSIN max firing rate | Wilcoxon rank sum | 0.50 | 6 | 3 | 11 | 7 |
| Figure 5—figure supplement 1C | Pyr resting potential | Wilcoxon rank sum | 0.94 | 13 | 8 | 17 | 11 |
| Figure 5—figure supplement 1D | Pyr input resistance | Wilcoxon rank sum | 0.80 | 13 | 8 | 17 | 11 |
| Figure 5—figure supplement 1E | Pyr halfwidth | Wilcoxon rank sum | 0.46 | 13 | 8 | 17 | 11 |
| Figure 5—figure supplement 1F | Pyr max firing rate | Wilcoxon rank sum | 0.93 | 13 | 8 | 17 | 11 |