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. 2008 Dec 10;36(4):198–203. [Article in Spanish] doi: 10.1157/13078612

Fibrilación auricular como factor de riesgo de acontecimientos cerebrovasculares en personas mayores de 65 años: ¿es adecuada la práctica clínica en profilaxis anticoagulante?

Auricular fibrillation as a risk factor of cerebrovascular events in the over-65S. Is clinical practice in anticoagulant prophylaxis adequate?

P Gayoso Diz a,, R Calle Custodio b, A Prieto Maroto b, D Herrera Calvo b, AI Sala López b, MD Gómez Mosquera b
PMCID: PMC7684480  PMID: 16153373

Abstract

Aim

To describe the clinical practice in antithrombotic therapy to prevent stroke in older patients with atrial fibrillation (AF).

Design

Cross-sectional study.

Setting

Ourense's area with 95 840 inhabitants over 65 years.

Participants

Patients over 65 with non rheumatic AF, chronic or paroxistic; 411 cases, 69.6% older than 75 year.

Main measurements

Demographic characteristics, personal history, stroke risk, diagnostic characteristics of AF, antithrombotic treatment, and its adequacy.

Results

Only 33% high risk patients received oral anticoagulation (OCA) with warfarin at diagnosis. Some features were found to be significant independent risk factors for OCA: age (older than 75 vs 65-74 years; odds ratio =0.32; 95% confidence interval, 0.18-0.59), and prior stroke (odds ratio =2.02; 95% confidence interval, 1,16-3,55).

Conclusions

Warfarin prophylactic is insufficiently prescribed, especially in older than 75 years (with high baseline risk of stroke and no counter-indications). There was inadequate prescription in 73.4% cases.

Key words: Atrial fibrillation, Elderly, Stroke prevention, Antithrombotic therapy

Bibliografía

  • 1.Kannel W.B., Abbot R.D., Savage D.D., McNamara P.M. Epidemiological features of chronic atrial fibrillation: the Framingham Study. N Engl J Med. 1982;306:1018–1022. doi: 10.1056/NEJM198204293061703. [DOI] [PubMed] [Google Scholar]
  • 2.Connolly S.J., Laupacis A., Gent M., Roberts R.S., Cairns F.A., Joyner C. Canadian Atrial Fibrillation Anticoagulation (CAFA) Study. J Am Coll Cardiology. 1991;18:349–355. doi: 10.1016/0735-1097(91)90585-w. [DOI] [PubMed] [Google Scholar]
  • 3.Albers G.W., Atwood J.E., Hirsh J., Sherman D.G., Hughes R.A., Connolly S.J. Stroke prevention in non valvular atrial fibrilation. Ann Intern Med. 1991;115:727–736. doi: 10.7326/0003-4819-115-9-727. [DOI] [PubMed] [Google Scholar]
  • 4.Benjamin E.J., Levy D., Vaziri S.M., D’Agostino R.B., Belanger A.J., Wolf P.A. Independent risk factors for atrial fibrillation in a population-based cohort: the Framingham Heart Study. JAMA. 1994;271:840–844. [PubMed] [Google Scholar]
  • 5.Wolf P.A., Abbot R.D., Kannel W.B. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke. 1991;22:983–988. doi: 10.1161/01.str.22.8.983. [DOI] [PubMed] [Google Scholar]
  • 6.Roquer J. Problemas neurológicos. In: Martín Zurro A., Cano Pérez J.F., editors. Atención primaria. Conceptos, organización y práctica clínica. 4.ª ed. Harcourt-Brace; Barcelona: 1999. pp. 1210–1221. [Google Scholar]
  • 7.Atrial Fibrillation Investigators Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from the randomised controlled trialsArch Intern Med. 1994;154:1449–1457. [PubMed] [Google Scholar]
  • 8.Hart R.G., Benavente O., McBride R. Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a metaanalysis. Ann Intern Med. 1999;131:492–501. doi: 10.7326/0003-4819-131-7-199910050-00003. [DOI] [PubMed] [Google Scholar]
  • 9.Segal J.B., McNamara R.L., Miller M.R. Prevention of thromboembolism in atrial fibrillation: a meta-analysis of trials of anticoagulants and antiplatelet drugs. J Gen Intern Med. 2000;15:56–67. doi: 10.1046/j.1525-1497.2000.04329.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Albers G.W., Dalen J.E., Laupacis A. Antithrombotic therapy in atrial fibrillation. Chest. 2001;119(Suppl):194–206. doi: 10.1378/chest.119.1_suppl.194s. [DOI] [PubMed] [Google Scholar]
  • 11.Fuentes López E., Martín F., Salgado Ordóñez A., Sánchez Silvestre F., Martos Crespo, González Correa J.A. Valoración del tratamiento antitrombótico en pacientes con fibrilación auricular crónica no valvular. Aten Primaria. 1998;22:172–175. [PubMed] [Google Scholar]
  • 12.Bungard T.J., Ghali W.A., Teo K.K., McAlister F.A., Tsuyuki R.T. Why do patients with atrial fibrillation not receive warfarin? Arch Intern Med. 2000;160:41–46. doi: 10.1001/archinte.160.1.41. [DOI] [PubMed] [Google Scholar]
  • 13.Córdoba R., Hernández A.C. Fibrilación auricular en el anciano. FMC. 1999;6:240–248. [Google Scholar]
  • 14.Brotons C., Moral I., Antón J.J. Tratamiento preventivo de la fibrilación auricular no reumática: de la eficacia de los ensayos clínicos a la efectividad en la práctica clínica. Aten Primaria. 1997;20:367–371. [PubMed] [Google Scholar]
  • 15.American Geriatrics Society The use of oral anticoagulants (warfarin) in older people. J Am Geriatr Soc. 2002;50:1439–1445. doi: 10.1046/j.1532-5415.2002.50380.x. [DOI] [PubMed] [Google Scholar]
  • 16.Fahey T., Rimmer J., Godfrey P. Risk stratification in the management of atrial fibrillation in the community. Br J Gen Pract. 1999;49:295–296. [PMC free article] [PubMed] [Google Scholar]
  • 17.Protheroe J., Fahey T., Montgomery A.A., Peters T.J. The impact of patients’ preferences on the treatment of atrial fibrillation: observational study of patient based decision analysis. BMJ. 2000;320:1380–1384. doi: 10.1136/bmj.320.7246.1380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Gage B.F., Cardinalli A.B., Owens D.K. The effect of stroke and stroke prophylaxis with aspirin or warfarin on quality of life. Arch Intern Med. 1996;156:1829–1836. [PubMed] [Google Scholar]
  • 19.Solomon N.A., Glick H.A., Russo C.J., Lee J., Schulman K.A. Patient preferences for stroke outcomes. Stroke. 1994;25:1721–1725. doi: 10.1161/01.str.25.9.1721. [DOI] [PubMed] [Google Scholar]
  • 20.Devereaux P., Anderson D.R., Gardner M.J. Differences between perspectives of physicians and patients on anticoagulation in patients with atrial fibrillation: observational study. BMJ. 2001;323:1218–1222. doi: 10.1136/bmj.323.7323.1218. [DOI] [PMC free article] [PubMed] [Google Scholar]

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