Table 4: Linear regression models of variables affects the magnitude of the antibody response against the SARS-CoV-2 spike glycoprotein.

The IgG, IgA and IgM ratios were used as dependent variables and participants’ age, sex, ethnicity, body mass index, time from symptom onset, the index of multiple deprivation score, whether an individual isolated because they directly experienced symptoms or isolated because a family member experienced symptoms and public transport use in the two weeks prior to isolation were used as independent variables. Odds ratios (OR) and 95% confidence intervals (CI) are provided. For continuous variables, the OR represents the increase in immunoglobulin ratio associated with each unit increase in that variable. For categorical variables, the OR represents the increase in immunoglobulin ratio associated the variable in parenthesis.

IgG ration					IgA ration					IgM ration
Variable	OR (95% CI)	t	P-value		Variable	OR (95% CI)	t	P-value		Variable	OR (95% CI)	t	P-value
Age	0.03 (0.01–0.05)	2.89	0.0043		Age	0.01 (−0.01–0.03)	1.21	0.26		Age	0.00 (−0.01–0.02)	0.03	0.97
Sex (Female)	−0.02 (−0.51–0.48)	0.07	0.95		Sex (Female)	0.17 (−0.27–0.60)	0.78	0.45		Sex (Female)	0.14 (−0.19–0.48)	0.84	0.40
Ethnicity (BAME)	0.98 (0.49–1.47)	3.95	0.0001		Ethnicity (BAME)	−0.05 (−0.46–0.35)	0.25	0.80		Ethnicity (BAME)	0.42 (0.09–0.76)	2.53	0.02
BMI	0.07 (0.03–0.11)	3.62	0.0004		BMI	−0.02 (−0.05–0.01)	1.42	0.15		BMI	0.00 (−0.03–0.04)	0.22	0.83
Time from symptom onset	−0.01 (−0.03–0.01)	1.27	0.22		Time fron symptom onset	−0.02 (−0.04–0.01)	2.76	0.007		Time from symptom onset	−0.01 (−0.02–0.01)	1.00	0.32
Index of multiple deprivation	0.16 (−0.13–0.45)	1.09	0.28		Index of multiple deprivation	−0.10 (−0.36–0.16	0.78	0.44		Index of multiple deprivation	−0.17 (−0.41–0.07)	1.43	0.32
Primaiy symptoms	0.19 (−0.03–0.66)	0.78	0.44		Primary symptoms	0.27 (−0.14–0.67)	1.31	0.19		Primary symptoms	0.25 (−0.16–0.65)	1.24	0.22