Table 3.
Secondary outcomes | Unadjusted odds ratio (95% CI) | P value | Adjusted odds ratio (95% CI) | P value |
---|---|---|---|---|
In-hospital cardiac, pulmonary, or renal complications* | 0.74 (0.66 to 0.83) | <0.001 | 0.73 (0.63 to 0.85) | <0.001 |
Major adverse cardiac event† | 0.80 (0.69 to 0.92) | <0.001 | 0.72 (0.60 to 0.87) | <0.001 |
Heart failure | 0.90 (0.71 to 1.13) | 0.39 | ‡ | ‡ |
Pneumonia | 0.74 (0.57 to 0.96) | 0.02 | 0.81 (0.60 to 1.11) | 0.19 |
Venous thromboembolism | 0.42 (0.24 to 0.73) | 0.001 | ‡ | ‡ |
Deep vein thrombosis | 0.52 (0.29 to 0.95) | 0.04 | ‡ | ‡ |
Pulmonary embolism | 0.17 (0.04 to 0.70) | 0.004 | ‡ | ‡ |
Acute kidney injury | 0.48 (0.34 to 0.67) | <0.001 | ‡ | ‡ |
Cerebrovascular event§ | 0.38 (0.16 to 0.90) | 0.03 | ‡ | ‡ |
Hospital readmissions | 1.00 (0.91 to 1.10) | 0.98 | 0.59 (0.32 to 1.10) | 0.11 |
Length of hospital stay (days) | Absolute difference −0.2 (−0.1 to −0.2) | <0.001 | Absolute difference −0.5 (−0.3 to −0.6) | <0.001 |
It was decided a priori to analyse the adjusted odds of in-hospital cardiopulmonary and renal complications as a composite outcome to improve power.
Includes acute coronary syndrome, heart failure, ventricular arrhythmia, or cardiac arrest.
Number of events was too low to allow for fully adjusted regression modelling.
Post hoc analysis; includes transient ischaemic attack and ischaemic or haemorrhagic stroke.