Table 4.

The area under the receiver operating characteristic (ROC) curve (AUC) of the studied biomarkers and evaluation of their cut off.

All Patients
Parameter	AUC	95% confidence intervals	Cut off	Sensitivity	Specifity	p value
He4	0.92	0.898 to 0.95	359	80	92	<0.0001
IL-6	0.91	0.88 to 0.934	212	73	93	<0.0001
RCP	0.616	0.573 to 0.658	88	68	52	<0.0001
PSP	0.81	0.77 to 0.84	1179	75	71	<0.0001
PCT	0.701	0.66 to 0.740	0.37	65	68	<0.0001
D-Dimer	0.721	0.680 to 0.759	3757	51	81	<0.0001
Mild patients
Parameter	AUC	95% confidence intervals	Cut off	Sensitivity	Specifity	p value
He4	0.978	0.955 to 0.991	198	90	94	<0.0001
IL-6	0.96	0.93 to 0.979	96	88	98	<0.0001
RCP	0.705	0.653 to 0.753	88	68	64	<0.0001
PSP	0.873	0.832 to 0.907	1179	55	94	<0.0001
PCT	0.622	0.565 to 0.677	1.07	36	86	<0.0001
D-Dimer	0.753	0.703 to 0.798	3757	51	89	<0.0001
Severe patients
Parameter	AUC	95% confidence intervals	Cut off	Sensitivity	Specifity	p value
He4	0.897	0.857 to 0.929	425	74.14	95.21	<0.0001
IL-6	0.851	0.806 to 0.890	212	73	94	<0.0001
RCP	0.513	0.455 to 0.542	184	34	72	<0.0001
PSP	0.738	0.684 to 0.786	2069	50	89.89	<0.0001
PCT	0.622	0.565 to 0.677	1.07	36	86	<0.0001
D-Dimer	0.683	0.628 to 0.735	5284	38.9	87.7	<0.0001